葡萄次生代谢UDP-糖基转移酶研究进展

Research Progress on UDP-glycosyltransferases in Grape Secondary Metabolism Pathway

UDP-糖基转移酶催化糖基转移反应,将糖基从活化的供体分子转移到受体分子上,从而调节受体分子在细胞内和机体内的性质,如生物活性、溶解性、可转运性。糖苷化是葡萄次生代谢很普遍的修饰反应,在次生代谢产物合成、贮存方面发挥重要功能。综述了与葡萄次生代谢产物生物合成相关的UDP-糖基转移酶的生化及分子生物学研究进展,并对今后这一领域需要进一步研究的问题作了讨论。

Uridine diphosphate（UDP）glycosyltransferases（UGTs）catalyze the transfer of glycosyl residues from activated nucleotide sugars to a wide range of acceptor molecules（aglycones）,thus regulating properties of the acceptors,such as bioactivity,solubility and transport within the cell and throughout the organism.Glycosylation is a widespread modification in grape secondary metabolism pathway.It is involved in various functions,including the biosynthesis and storage of secondary compounds.Here,we highlight recent progress in biochemistry and molecular biology characteristics of UGTs in grape secondary metabolism pathway.The prospect for further research of these glycosyltransferases was also discussed.