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肿瘤侵袭转移相关microRNAs的研究进展 被引量：3

Advances of microRNAs Correlated with Invasion and Metastasis of Tumors
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摘要 近年来大量研究表明microRNAs（miRNAs）与人类多种肿瘤的发生发展及侵袭转移存在着密切关系,miRNAs可能成为一类新的致癌基因或抑癌基因,它们通过抑制靶mRNA翻译或诱导靶mRNA降解在转录后水平调控基因表达,具有癌基因或抑癌基因的功能,参与肿瘤的发生、发展及侵袭转移。
作者 王海兵 陈晓峰 王和勇 张慧君
机构地区 同济大学附属上海市肺科医院胸外科
出处 《中国肺癌杂志》 CAS 2010年第2期144-148,共5页 Chinese Journal of Lung Cancer
基金 国家自然科学基金(No.30872553)和(No.30800631)资助~~
关键词 肿瘤侵袭转移 MICRORNAS 抑癌基因 miRNAs 调控基因表达 RNA降解 致癌基因 mRNA
分类号 R730.2 [医药卫生—肿瘤]
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  • 1Pillai RS. MicroRNA function: multiple mechanisms for a tiny RNA? RNA 2005; 11:1753-1761.
  • 2Zamore PD, Haley B. Ribo-gnome: the big world of small RNAs. Science 2005; 309:1519-1524.
  • 3Bartel DP. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 2004; 116:281-297.
  • 4Fitzgerald K. RNAi versus small molecules: different mechanisms and specificities can lead to different outcomes. Curr Opin Drug Discov Dev 2005, 8:557-566.
  • 5Brennecke J, Stark A, Russell R.B, Cohen SM. Principles of microRNA-target recognition. PLoS Biol.2005; 3:e85.
  • 6Croce CM, Calin GA. miRNAs, cancer, and stem cell division. Cell 2005; 122:6-7.
  • 7Chen CZ, Li L, Lodish HF, Bartel DE MicroRNAs modulate hematopoietic lineage differentiation. Science 2004; 303:83- 86.
  • 8Hwang HW, Mendell JT. MicroRNAs in cell proliferation, cell death, and tumorigenesis. Br J Cancer 2006; 94:776-780.
  • 9Hammond SM. MicroRNAs as oncogenes. Curr Opin Genet Dev 2006; 16:4-9.
  • 10Esquela-Kerscher A, Slack FJ. Oncomirs - microRNAs with a role in cancer. Nat Rev Cancer 2006; 6:259-269.

共引文献205

同被引文献31

  • 1Ju J, Jiang J, Fesler A. miRNA: the new frontier in cancer medicine[J]. Future ivied Chern ,2013, 5(9): 983-985.
  • 2Jusufovic E, Rijavec M, Keser D, et al . let-Tb and miR-126 are down-regulated in tumor tissue and correlate with mi- crovessel density and survival outcomes in non-small-cell lung cancer[J]. PLoS One ,2012, 7(9): e45577.
  • 3Park S, Minai-Tehrani A, Xu CX, et al. Suppression of A549 lung cancer cell migration by precursor let-Tg microR- NA[J]. Mol Med Rep ,2010, 3(6), 1007-1013.
  • 4Gao W, Lu X, Liu L, et al . MiRNA-21 : a biomarker predic- tive for platinum-based adjuvant chemotherapy response in patients with non-small cell lung cancer[J]. Cancer Biol Ther ,2012, 13(5): 330-340.
  • 5Wang XC, Tian LL, Jiang XY, et al . The expression and function of miRNA-451 in non-small cell lung cancer[J].CancerLett ,2011, 311(2): 203-209.
  • 6Yanaihara N, Caplen N, Bowman E, et al . Unique microR- NA molecular profiles in lung cancer diagnosis and prognosis [J]. Cancer Cell ,2006, 9(3): 189-198.
  • 7Chen C, Ridzon DA, Broomer AJ, et al . Real-time quantifi- cation of microRNAs by stem-loop RT-PCR [J ]. Nucleic Acids Res .2005, 33(20), e179.
  • 8Kong W, Yang H, He L, et al . MicroRNA-155 is regulated by the transforming growth factor beta/Smad pathway and contributes to epithelial cell plastieity by targeting RhoA[J]. Mol Cell Biol ,2008, 28(22): 6773-6784.
  • 9Gironella M, Seux M, Xie MJ, et al . Tumor protein 53-in- duced nuclear protein 1 expression is repressed by miR-155, and its restoration inhibits pancreatic tumor development[J]. Proc Natl Acad Sci USA ,2007, 104(41): 16170-16175.
  • 10Kong W, He L, Coppola M, et al . MicroRNA-155 regulates cell survival, growth, and chemosensitivity by targeting FOXO3a in breast eancer[J]. J Biol Chem ,2010, 285(23): 17869-17879.

引证文献3

二级引证文献19

中国肺癌杂志
2010年 第2期

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