短效达必佳两种降调节方案在控制性超排卵中的效果比较

Study on the Effect of Two Kinds of Down-regulation Protocols by Shortacting Triptorelin in Controlled Ovarian Hyperstimulation (COH)

目的:比较短效达必佳2种降调节方案在控制性超排卵(COH)中的效果。方法:回顾性分析比较本中心接受COH降调节方案的261个周期,根据达必佳用量及用法的不同分成A组:部分半量方案,95个周期;B组:半量方案,166个周期,比较组间的超促排卵情况及妊娠结局。结果:A组Gn用量(75IU/支)、Gn总天数、IVF受精率和优质胚胎率均较B组高(P<0.05);Gn启动日FSH水平和hCG注射日LH水平较B组低(P<0.05);着床率、临床妊娠率、继续妊娠率A组与B组比差异无统计学意义(P<0.05),但有增高趋势。结论:黄体中期短效达必佳0.1mg/d×14d降调节效果比0.05mg/d降调节好。

Objective： To compare the effect of two kinds of down-regulation protocols by short-acting triptorelin in controlled ovarian hypersfimulation （COH）. Methods： A retrospective analysis was performed on a total of 261 cycles. They were divided into two groups according to the different dosage and usage of short-acting triptorelin： group A, part-semidosage （n= 95 cycles）; group B, semidosage （n= 166 cycles）. Comparison was performed in the aspects of COH and pregnancy outcome between the two groups. Results： Compared with group B, the dosage of Gn, IVF fertilization rate and good quality embryo rate of group A were higher （P〈0.05）. In group A, the level of FSH on the starting day of Gn and the level of LH on the day of hCG administration were lower than those of group B （P〈0.05）. The implantation rate, clinical pregnancy rate and on-going pregnancy rate were all higher in group A than in group B, but there were no significant differences. Conclusion： Using 0.1 mg short-acting triptorelin for 14 d could have a better down-regulation effect than using 0.05 mg since the midluteal phase of the previous menstrual cycle.