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肠促胰岛素在减肥手术治疗肥胖2型糖尿病患者中的作用 被引量：4

Remission of type 2 diabetes in obese patients after bariatric surgery:the role of incretins
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摘要 肥胖和2型糖尿病的患病率呈逐年增高的趋势.减肥手术作为减轻体质量的有效方法,近年来逐渐得到广泛的应用.其主要分为限制型手术、吸收不良型手术及联合型手术.减肥手术在减轻体质量的同时也使肥胖患者的糖尿病得到了缓解,但其缓解糖尿病的机制目前尚不完全清楚.除了体质量减轻、摄食减少外,关于肠促胰岛素在减肥手术中的作用也受到了越来越多的重视.本文对减肥手术的术式、疗效、安全性及治疗糖尿病的可能机制进行讨论. The prevalence of obesity and type 2 diabetes has increased over recent decades. Bariatric surgery has been widely used in clinical practice. There are three categories of bariatric surgery： restrictive surgery, malabsorptive surgery, and combined restrictive and malabsorptive surgery. Bariatric surgery causes not only weight loss but also a remarkable and durable remission of type 2 diabetes mellitus. However, the mechanism of diabetes resolution remains unclear. In addition to weight loss and food intake restriction, incretins also seem to contribute to the resolution of type 2 diabetes following bariatric surgery.In this article, we will review the efficacy and safety of various bariatric procedures and the mechanism of diabetes resolution resulting from bariatric surgery.
作者 侯文芳 刘国强 洪天配
机构地区 北京大学第三医院内分泌科
出处 《世界华人消化杂志》 CAS 北大核心 2010年第4期324-328,共5页 World Chinese Journal of Digestology
基金 国家自然科学基金资助项目 No.30771032 No.30700879 国家973重大项目子课题基金资助项目 No.2006CB503900 国家863重大项目子课题基金资助项目 No.2006AA02A112 北京市自然科学基金资助项目 No.7062067~~
关键词 减肥手术 2型糖尿病 肠促胰岛素 Bariatric surgery Type 2 diabetes mellitus Incretin
分类号 R587.1 [医药卫生—内分泌]
  • 相关文献

参考文献31

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二级参考文献22

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共引文献24

同被引文献63

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引证文献4

二级引证文献49

世界华人消化杂志
2010年 第4期

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