1例股骨下段孤立性浆细胞瘤的诊治并文献综述

A case report of solitary plasmacytomas of bone located in the lower femur

[目的]报道1例股骨下段孤立性浆细胞瘤的诊治并综述相关文献。[方法]查阅有关骨内孤立性浆细胞瘤的文献,结合1例发生于股骨下段孤立性浆细胞瘤的诊治过程,从发病、诊断、治疗、预后等方面认识该罕见病。[结果]孤立性浆细胞是一种以单克隆浆细胞失控增殖为特征的少见肿瘤;活检病理及免疫细胞化学检测确诊后,局部彻底切除和放疗是当前较有效的治疗方案;该病的预后和M蛋白水平及持续时间、原发瘤大小、有无复发等因素有关。[结论]孤立性浆细胞瘤是一种易向多发性骨髓瘤恶变的罕见肿瘤,及时的确诊、手术、放疗以及长期随访对改善预后很重要。

The original articles in recent years about solitary plasmacytomas of bone（SPB） were reviewed in terms of etiopathogenisis,diagnosis,therapy plan and prognosis.SPB is a rare tumor characterized by the uncontrolled proliferation of plasmocytes.After it is diagnosed by local biopsy and further immunocytochemistry test,the wide excision or thorough curettage in corporation with radiotherapy is the choice of treatment.The primary tumor size,the content and lasting time of M proteins or local recurrence evidence after properly treated are all closely correlated with SPB prognosis.SPB is a rare tumor with a tendency to grow into multiple myeloma.The correct diagnosis and treatmert in time and long-term fellow up are vital factors for prognosis.