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举重运动员肌钙蛋白T相关基因多态性分析 被引量：2

The Polymorphism of the Troponin T-related Gene in Elite Weightlifters
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摘要 目的:研究优秀举重运动员骨骼肌肌钙蛋白T(TnT)基因多态性分布特征,为举重运动员选材提供分子遗传学标记的参考。方法:采用扩增片段长度多态性(PCR-RFLP)方法分别测定优秀举重运动员和普通对照人群sTnT基因SNP/C7761T和fTnT基因SNP/T7955C的分布特征。结果:sTnT基因SNP/C7761T和fTnT基因SNP/T7955C多态位点均符合H-W平衡;运动员组sTnT基因SNP/C7761T分布和fTnT基因SNP/T7955C分布与对照组之间均无显著性差异。结论:sTnT基因SNP/C7761T和fTnT基因SNP/T7955C不能作为举重运动员选材的分子遗传学标记。 Objective To validate whether troponin T （TNT） gene can be used as molecular genetic markers for selection of elite weightlifters.Methods Using PCR-RFLP（Restriction Fragment Length Polymorphism） to measure the Characteristics of distribution of SNP/C7761T in sTnT gene and SNP/T7955C in fTnT gene of elite athletes group （A） and normal control group（C）,Resuks（1） Polymorphic loci of SNP/C7761T in sTnT gene and SNP/T7955C in fTnT gcne were ~t with the B-W equilibrium. （2） There was no significant difference of SNP/C7761T in sTnT gene and SNP/T7955C i a, fTnT gene between elite athlete group and normal control group. Conclusion SNP/C7761T in sTnT gene and SNP/T7955C in fTnT gene can not be used as molecular genetic markers for selection of elite weighthifters
作者 魏悦爽 胡扬 许春燕 李燕春 杨晓琳
机构地区 北京体育大学
出处 《中国运动医学杂志》 CAS CSCD 北大核心 2010年第1期4-7,共4页 Chinese Journal of Sports Medicine
基金 国家科技部资助项目(2005DKA21300-9)
关键词 肌钙蛋白T 基因多态性 举重运动员 Troponi T,gene polymorphism,elite weightlifters
分类号 R87 [医药卫生—运动医学]
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参考文献15

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二级参考文献5

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同被引文献17

  • 1王智,丁雪琴,赵开强.对我国高水平举重运动员的调查：理想比赛心理状态的特点及其影响因素[J].体育科学,2007,27(9):49-53. 被引量：12
  • 2Reese JM,Fisher SD,Robbins DP. Exertional rhabdomyolysis:attrition through exercise,a case series and review of the literature[J].J Spec Oper Med,2012,(3):52-56.
  • 3Landau ME,Kenney K,Deuster P. Exertional rhabdomyolysis:a clinical review with a focus on genetic influences[J].J Clin Neuromuscul Dis,2012,(3):122-136.
  • 4Heled Y,Bloom MS,Wu TJ. CK-MM and ACE genotypes and physiological prediction of the creatine kinase response to exercise[J].{H}Journal of Applied Physiology,2007,(2):504-510.
  • 5Devaney JM,Hoffman EP,Gordish-Dressman H. IGF-Ⅱ gene region polymorphisms related to exertional muscle damage[J].{H}Journal of Applied Physiology,2007,(5):1815-1823.
  • 6Yamin C,Duarte JA,OliveiraJM. IL6 (-174) and TNFA (-308) promoter polymorphisms are associated with systemic creatine kinase response to eccentric exercise[J].{H}European Journal of applied Physiology,2008,(3):579-586.
  • 7Hubal M J,Devaney JM,Hoffman EP. CCL2 and CCR2 polymorphisms are associated with markers of exercise-induced skeletal muscle damage[J].{H}Journal of Applied Physiology,2010,(6):1651-1658.
  • 8Clarkson PM,Hoffman EP,Zambraski E. ACTN3 and MLCK genotype associations with exertional muscle damage[J].{H}Journal of Applied Physiology,2005,(2):564-569.
  • 9Barrey E,Jayr L,Mucher E. Transcriptome analysis of muscle in horses suffering from recurrent exertional rhabdomyolysis revealed energetic pathway alterations and disruption in the cytosolic calcium regulation[J].{H}Animal Genetics,2012,(3):271-281.
  • 10Edwards JG,Newtont JR,Ramzan PH. The efficacy of dantrolene sodium in controlling exertional rhabdomyolysis in the Thoroughbred racehorse[J].{H}EQUINE VETERINARY JOURNAL,2003,(7):707-711.

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中国运动医学杂志
2010年 第1期

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