慢性粒细胞白血病的靶向治疗
摘要
慢性粒细胞白血病（chronic myeloid leukemia，CML）是一种造血干细胞恶性克隆性疾病，其特征性的Ph染色体t（9；22）可导致癌性融合基因BCR／ABL的产生，后者编码蛋白具有酪氨酸激酶活性，在CML的发病和疾病演变中起着关键作用[1-2]。1979年首次报道异基因造血干细胞移植（hemapoietic stem cell transplantation, HSCT）治疗CML慢性期患者成功以后，由于HSCT能清除Ph染色体阳性细胞克隆，
出处
《国际输血及血液学杂志》
CAS
2010年第1期8-11,共4页
International Journal of Blood Transfusion and Hematology
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