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粘着斑激酶在血液系统中的作用 被引量：2

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摘要 粘着斑激酶（FAK）是一种非受体酪氨酸激酶，在正常细胞的生长周期、增殖分化、迁移运动及血管生成等过程中均发挥重要作用。研究表明，FAK在多种肿瘤细胞中高表达，在肿瘤细胞激活过程及侵袭转移中也起着关键作用，并已逐渐成为目前肿瘤治疗的新靶点。FAK在细胞内的信号转导通路是目前研究的热点，进一步认识其信号网络将有助于拓展新的治疗策略。本文就FAK在血液系统中的作用进行论述，并阐明FAK在造血生成、白血病、骨髓微环境的作用及信号转导机制。
作者 许吕宏(综述) 方建培(审校)
机构地区 中山大学孙逸仙纪念医院儿科
出处 《国际输血及血液学杂志》 CAS 2010年第1期57-60,共4页 International Journal of Blood Transfusion and Hematology
基金 中山大学青年教师培育项目资助（2009089）
关键词 粘着斑激酶 血液系统 信号转导 治疗策略
分类号 R735.7 [医药卫生—肿瘤] R733 [医药卫生—肿瘤]
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参考文献33

  • 1Schaller MD, Borgman CA, Cobb BS, et al. pp125FAK a structurally distinctive protein-tyrosine kinase associated with focal adhesions. Proe Natl Aead Sei U S A, 1992,89(11) :5192- 5196.
  • 2Golubovskaya VM, Kweh FA, Cance WG. Focal adhesion kinase and cancer. Histol Histopathol, 2009,24(4) :503-510.
  • 3Meng XN, Jin Y, Yu Y, et at. Charaeterisation of fihronectin- mediated FAK signalling pathways in lung cancer cell migration and invasion. Br J Cancer, 2009,101(2) : 327-334.
  • 4Cox BD, Natarajan M, Stettner MR, et al. New concepts regarding focal adhesion kinase promotion of cell migration and proliferation. J Cell Bioehem, 2006,99 (1) : 35-52.
  • 5Menashi EB, Loftus JC. Differential effects of Pyk2 and FAK on the hypertrophic response of cardiac myoeytes. Cell Tissue Res, 2009,337(2) :243-255.
  • 6van Nimwegen MJ, van de Water B. Focal adhesion kinase., a potential target in cancer therapy. Blochem Pharmaeol, 2007,73 (5) :597-609.
  • 7Lira ST, Mikolon D, Stupack DG, et al. FERM control of FAK function: implications for cancer therapy. Cell Cycle, 2008, 7 (15) :2306-2314.
  • 8Hitehcock IS, Fox NE, Prevost N, et al. Roles of focal adhesion kinase (FAK) in megakaryopoiesis and platelet function: studies using a megakaryocyte lineage specific FAK knockout. Blood, 2008,111(2) : 596-604.
  • 9Le Y, Zhu BM, Harley B, et al. SOCS3 protein developmentally regulates the chemokine receptor CXCR4-FAK signaling pathway during B lymphopoiesis. Immunity, 2007,27 (5) : 811- 823.
  • 10Le Y, Honczarenko M, Glodek AM, et al. CXC chemokine ligand 12-induced focal adhesion kinase activation and segregation into membrane domains is modulated by regulator of G protein signaling 1 in pro-B cells. J Immunol, 2005,174(5): 2582-2590.

同被引文献21

  • 1Maung K,Easty DJ,Hill SP,et al.Requirement for focal adhesion kinase in tumor cell adhesion.Oncogene,1999,18 (48):6824-6828.
  • 2Golubovskaya VM,Kweh FA,Cance WG.Focal adhesion kinase and cancer,Histol Histopathol,2009,24(4):503-510.
  • 3Vang J,Pan WH,Clawson GA,et al.Systemic targeting inhibitor of kappa B kinasc inhibits melanoma tumor growth.Cancer Rcs,2007,67(7):3127-3134.
  • 4Chan KT,Cortesio CL,Huttenlocher A.FAK alters invadopodia and focal adhesion composition and dynamics to regulate breast cancer invasion.Cell Biol,2009,185 (2):357-70.
  • 5Le Y,Xu L,Fang J,et al.FAK silencing inhibits leukemogenesis in BCR /ABL2 transformed hematopoietic cells.Am J Hematology,2009,84 (5):273-278.
  • 6Luo M,Fan H,Nagy T,et al.Mammary epithelial-specific ablation of the focal adhesion kinase suppresses mammary tumorigenesis by affecting mammary cancer stem/progenitor cells.Cancer Res,2009,69(2):466-474.
  • 7Halder J,Kamat AA,Landen CN,et al.Focal adhesion kinase targeting using in vivo short interfering RNA delivery in neutral liposomes for ovarian carcinoma therapy.Clin Cancer Res 2006,12(3):4916-4924.
  • 8Maung K, Easty DJ, Hill SP,et al. Requirement for focaladhesion kinase in tumor cell adhesion [J].Oncogene, 1999,18(48):6824-6828.
  • 9Hurwitz MD.The effect of mild temperature hyperthermia ontumor hypoxia and blood perfusion : relevance for radiotherapy,vascular targeting and imaging [J].Int J Hyper,2010,26 (3):224-231.
  • 10Chan KT,Cortesio CL, Huttenlocher A.FAK alters invadopodiaand focal adhesion composition and dynamics to regulate breastcancer invasion [J]. Cell Biol,2009,185(2): 357-370.

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国际输血及血液学杂志
2010年 第1期

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