血栓素合成酶抑制剂——奥札格雷的合成研究

THE SYNTHESIS OF OZAGREL-INHIBITOR OF THROMBOXANE SYNTHETASE

奥札格雷〔Ｏｚａｇｒｅｌ，化学名：（Ｅ）－４－〔（１－咪唑基甲基）〕苯基〕－２－丙烯酸，其结构式为：是世界上第一个上市的强力血栓素合成酶抑制剂，临床上应用于蛛网膜下腔出血术后症状的治疗，亦用于治疗支气管哮喘以及心绞痛。对其合成进行了研究，对某些反应条件进行了优化，产物经分析确证为我们所需产物。

Ozagrel chemical name:(E)- p-(lH-imidazol-1-methyl)phenyl -2-prope- noic acid (I) structure: is an efficient inhibitor of thromboxane that faced to market first in the world.It not only applies treatment to homorrhage of the subarachnold space but also applies treatment to bronchial asthma and angina pectoris.We reported the synthesis.Some conditions had been improved.After analysing we gained the product that we expected.