2型糖尿病合并高尿酸血症的中医证型与HCY和CRP的相关性研究

Research on the Relationship between CRP,HCY and TCM Syndrome Types of Diabetes Mellitus with Hymeperuricemia.

目的探讨2型糖尿病(DM)并高尿酸血症的中医证型与HCY和CRP的关系。方法选择T2DM并高尿酸血症患者103例,中医辨证分为风寒湿热证、痰瘀互阻证、气阴两虚证、阴阳两虚证4个证型,分别测定血清C反应蛋白CRP、血浆同型半胱氨酸(HCY)水平,并进行组间比较。结果各个证型组之间的年龄及病程、血压、血糖、血脂、CRP、HCY等血液指标经检验差异无统计学意义(P>0.05),CRP、HCY的总体均数水平超出正常范围。结论本病的证候分型与CRP、HCY化验指标无显著性相关,但本病的发展与CRP、HCY升高可能有关,推断痰瘀互阻是2型糖尿病合并高尿酸血症的病理变化。

Objective To study the value of CRP and HCY in each TCM type of T2DM with HUA and provide the basis for classification and treatment. Methods 103 cases of T2DM and HUA were divided into four Chinese medicine syndrome groups including deficinecy syndrome of wind - cold and damp - heat phlegm aceumlatoin and blood stasis syndrome deficineey syndrome of Qi and Yin deficine- cy syndrome of Yin and yang. Results The differentiation of TCM symptom among four groups was uncorrelated with the level of CRP and Hcy. But the serum CRP and HCY levels increased slighly as compared with those of normal control group. Conclusion The elevation of CRP and Hcy is closely correlated with phlegm aecumlation and blood stasis syndrome in patients of T2DM with HUA . As an inflammatoy biomarker, CRP and Hcy may be regard as two of the microcosmic indicators of toxin in Chinese medicine. They can be used as two important indexes of TCM syndrome differentiation of T2 DM with HUA.