结直肠癌中P53、nm23的表达研究及临床意义

Study of the Expression and Significance of P53 and nm23 in Colorectal Adenocarcinom.

目的探讨P53、nm23在结直肠癌中的表达及意义。方法用免疫组化法测定83例结直肠癌组织中P53、nm23的表达情况。结果 P53、nm23在结直肠癌中的表达强度与肿瘤的浸润深度、组织学分级、淋巴转移、远处转移、预后等有关(P<0.05),与病变部位、性别、年龄无关(P>0.05),二者的阳性表达呈负相关。结论 P53、nm23在结直肠癌的发生、转移及预后中起重要作用,检测P53、nm23有助于评价及判断预后。

Objective To study the expression and significance of P53 and nm23 in colorectal adenocarcinoma. Methods The expression of P53 and nm23 was examined by immunohistochemical technique in 83 cases of colorectal ad Results In colorectal adenocarcinoma, the positive intensities of P53 and nm23 was associated with tumour depth, histological grade, lymph node metastasis diseases and distant metastasis disease （ P 〈 0.01 ）, but not correlated with the tumour position, sex, age （ P 〉 0.05 ）. Conclusion P53 and nm23 may play an important role in the development and metastasis of colorectal adenocarcinoma. It is an useful marker for predictinng the prognosis of colorectal adenocareinoma.