Survivin在胆囊腺瘤组织中的表达意义及病理诊断价值分析

The Specific Expression and Pathological Diagnostic Value of Survivin in Gallbladder Adenoma

目的检测凋亡抑制蛋白Survivin在胆囊腺瘤的表达部位及形态特点,研究其与胆囊腺瘤发生、发展的相关性,并探讨其在胆囊腺瘤病理诊断中的应用价值。方法采用免疫组织化学技术检测25例胆囊腺瘤中Sur-vivin的表达。结果25例胆囊腺瘤中,23例Survivin蛋白胞浆阳性表达。其中21例核上表达,包括核上核样表达17例、核上泥沙样表达4例。另外胞浆弥漫表达2例。结论Survivin在胆囊腺瘤中高表达,具有向胆囊癌转化趋势,并且其特殊的表达部位及形态,在病理诊断中有着重要的应用价值。

Objective To evaluate the relative production and the clinical value of survivin in pathological diagnosis of gallbladder adenoma by observing the site of expression and the characteristics of survivin, the apoptosis inhibitor. Methods The expression of survivin in gallbladder adenoma was detected from 25 samples by immunohistochemical method SP. Results From a total of 25 gallbladder adenoma specimens 23 were reactive to survivin, which expressed on the cytoblast in cytoplasm with cytoblast - like 17, bedload - like 4 and diffusing 2 expression. Conclusion Survivin expression location and its characteristics may have important clinical value in pathological diagnosis of gall bladder adenoma.