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抑癌基因NPRL2的研究进展 被引量：6

Research advances in a tumor suppressor gene nitrogen permease regulator like 2
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摘要 抑癌基因NPRL2(nitrogen permease regulator-like 2)也称肿瘤抑制候选基因4(tumor suppressor candidate4,TUSC4),定位于人染色体3p21.3区域,广泛存在于人体各种组织中,在生物物种之间具有高度保守性;研究发现,在人类多种肿瘤组织(如肺癌、乳腺癌和肾癌等)中的表达明显降低。NPRL2基因具有参与DNA错配修饰、调控细胞周期信号转导以及诱导细胞凋亡的生物学功能。NPRL2基因失活与多种肿瘤的发生和发展有关。但其具体的抑瘤机制尚不清楚,有待于进一步研究。 Objective：Tumor suppressor gene nitrogen permease regulator like 2 （NPRL2）,also called tumor suppressor candidate gene 4 （TUSC4）,widely exists in all kinds of human tissues and is highly conserved in different kinds of biological species. The expression of NPRL2 is markedly decreased in many human tumor tissues,such as lung cancer,breast cancer,renal carcinoma,et al. NPRL2 is located in human chromosome 3p2.13,and participates in DNA mismatch modification,regulation of signal transduction du-ring cell cycle progression,and apoptosis induction. NPRL2 gene inactivation is related with the initiation and progression of several malignant tumors. The mechanism underlying the tumor-inhibiting activity of NPRL2 gene is not clear and needs to be further investigated.
作者 姚磊 吴德全 唐志强
机构地区 哈尔滨医科大学附属二院外科
出处 《肿瘤》 CAS CSCD 北大核心 2010年第2期160-163,共4页 Tumor
关键词 肿瘤 基因 肿瘤抑制 NPRL2 Neoplasms Genes, tumor suppressor Gene, NPRL2
分类号 R730.2 [医药卫生—肿瘤]
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参考文献30

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二级参考文献12

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共引文献13

同被引文献64

  • 1Lerman MI,Minna JD.The 630-kb lung cancer homozygous dele-tion region on human chromosome 3p21.3:identification and evalua-tion of the resident candidate tumor suppressor gene[J].CancerRes,2000,60(21):6116-6133.
  • 2Wang F,Grigorieva EV,Li J, et al.HYAL1 and HYAL2 inhibittumour growth in vivo but not in vitro[J].PLoS One,2008,3(8):3031.
  • 3Ji L,Nishizaki M,Gao B,et al.Expression of several genes in thehuman chromosome 3p21.3 homozygous deletion region by an ade-novirus vector results in tumor suppressor activities in vitro and vivo[J].Cancer Res,2002,62(9):2715-2720.
  • 4Ueda K,Kawashima H,Ohtani S,et al.The 3p21.3 tumor sup-pressor NPRL2 plays an important role in cisplatin-induced resist-ance in human non-small cell lung cancer cell[J].Cancer Res,2006,66(19):9682-9690.
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  • 6Li J,Wang FL,Haraldson K,et al.Functional characterization ofthe candidate tumor suppressor gene NPRL2/G21 located in 3p21.3C[J].Cancer Res,2004,64(18):6438-6443.
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  • 10LERMAN MI , M INNA JD. The 6302kb lung cancer homo- zygous deletion region on human chromosome 3p21. 3: iden- tification and evaluation of the resident candidate tumor supp ressor gene [J]. Cancer Res, 2000, 60(21): 6116--6133.

引证文献6

二级引证文献6

肿瘤
2010年 第2期

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