经典Wnt信号通路与精神分裂症

Canonical Wnt pathway and schizophrenia

精神分裂症是一种重性精神病性障碍,病因和机制尚未明确,但目前普遍认为是由多个微效基因协同并与环境因素共同作用导致的疾病。由多基因组成的信号通路及通路间的相互作用在精神分裂症发病中可能起重要作用。与中枢神经系统发育和功能维持密切相关的经典Wnt信号通路近年来受到较多关注。许多针对Wnt信号通路与精神分裂症的关联研究均表明,精神分裂症患者细胞内Wnt信号通路异常。文章就目前针对经典Wnt信号通路在精神分裂症发病中潜在作用的相关研究作一综述。

Schizophrenia is one of the most severe psychiatric disorders. Although the etiology is unknown, schizophrenia appears to be a polygenic disorder associated with environmental factors. There are evidences that intracellular signaling plays an important role in the pathogenesis of schizophrenia. Canonical Wnt pathway, which is closely related to the development and function maintenance of central nervous system, have drawn wide attention. Evidences for potential disturbances of Wnt signaling pathways in schizophrenia have accumulated, which are in favour of the hypothesis that Wnt signaling alterations may be important in the pathogenesis of schizophrenia. The research advances in the relationship between canonical Wnt signaling pathway and schizophrenia are reviewed in this paper.