丝状真菌异源蛋白高效表达的研究进展

Advance in Research on High Expression of Heterologous Protein in Filamen- tous Fungi

丝状真菌作为细胞工厂在生物技术领域被广泛应用于生产药物、化学试剂和酶类。近年来,丝状真菌基因组学领域取得了快速发展,利用丝状真菌表达异源蛋白也越来越受到重视。本文从基因表达与调控、蛋白质分泌途径及丝状真菌菌株等方面对丝状真菌高效表达异源蛋白的最新研究进展作一综述。

Filamentous fungi are widely used in biotechnology as cell factories for the production of pharmaceuticals, chemi- cals and enzymes. The study of gene function in filamentous fungi is a field of research that has made great advances in very recent years. Filamentous fungi are widely developed for the production of heterologous proteins. This review describes the recent advances in research on high expression of heterologous protein in filamentous fungi, such as gene expression and control, protein secretion pathway and filamentous fungus strains.