摘要
离子通道病是遗传性心律失常的主要病因,可分为由钠离子通道、钾离子通道和钙离子通道基因变异所致的心律失常综合征。其机理是编码心肌细胞离子通道亚单位的基因变异,导致离子通道功能的变化,进而引起异常的心电活动,临床表现为恶性心律失常。
Ion channelopathies are the mainly etiopathogenisis of inherited arrhythmia.Those arrhythmia syndromes are commonly caused by ion channel gene mutation,which can be classified as sodium,potassium and calcium ion channel mutation.Changes in the genes encoding for cardiac ion channel subunits produce modification in the function of the channels,and cause the dysfunctions of cardiac electrical activity;and the clinical manifestation is malignant arrhythmia.
出处
《浙江大学学报(医学版)》
CAS
CSCD
北大核心
2010年第1期97-102,共6页
Journal of Zhejiang University(Medical Sciences)