依达拉奉联合高压氧治疗脑梗死64例疗效分析

Effect of edaravone combined with hyperbaric oxygen in the treatment of cerebral infarction

目的观察依达拉奉联合高压氧治疗急性脑梗死的临床疗效。方法选择急性脑梗死患者119例,随机分为治疗组64例和对照组55例。对照组加用依达拉奉,治疗组应用依达拉奉同时联合高压氧治疗,其余治疗与对照组相同。治疗前后对患者用美国国立卫生院卒中患者神经机能缺损评分量表(Na-tional Institutes of Health Stroke,NIHSS)评分。结果治疗后21d,两组临床疗效比较,差异有统计学意义。治疗后治疗组NIHSS评分与对照组比较差异有统计学意义(P<0.01),且不同治疗时间的NIHSS评分差异亦有统计学意义(P<0.01)。结论依达拉奉联合高压氧辅助治疗急性脑梗死,对脑组织有显著保护作用。

Objective To investigate the clinic effect of edaravone combined with hyperbaric oxygen on acute cerebral infarction. Methods 119 cases with acute cerebral infarction were randomly divided into the trial group （64 cases） and control group （55 cases）. The control group received edaravone, while the trial group received edaravone conbined with hyperbaric oxygen treatment, the rest of the treatments are the same as the control group. National Institutes of Health Stroke （NIHSS） was assessed before and after treatment. Results After 21 days treatment, there was a significant difference of efficacy between the trial group and control group （ P 〈 0.05）. The difference of NIHSS between the trial group and control group was significant （P 〈0.01 ）. Moreover,there were significant differences in different time of therapy （ P 〈 0.01 ）, Conclusion Edaravone combined with hyperbaric oxygen is effective in treatment of acute cerebral infarction.