四逆汤合小青龙汤加减治疗AECOPD疗效观察

Therapeutic effects of modified formula sini tang and xiaoqinglong tang on acute exacerbation chronic obstructive pulmonary disease

目的:观察中西医结合治疗慢性阻塞性肺疾病(COPD)急性加重期的临床疗效。方法:将48例COPD急性加重期患者随机分为两组:对照组24例采用西医常规治疗;治疗组24例在对照组治疗基础上加用四逆汤合小青龙汤加减。两组均以15d为1疗程。观察临床疗效及治疗前后动脉血氧分压(PaO2)、二氧化碳分压(PaCO2)和第1s用力呼气肺容量(FEVl)的变化。结果:两组治疗前后临床疗效的显效率、总有效率比较,差异有非常显著性或显著性意义(P<0.01,P<0.05)。两组治疗前后PaO2、PaCO2、FEVI比较,差异均有显著性意义(P<0.05)。结论:四逆汤合小青龙汤加减治疗COPD急性加重期优于常规西医治疗。

Objective：To observe the therapeutic effects of combined treatment with traditional Chinese medicine and western medicine on chronic obstructive pulmonary disease（COPD）during the acute exacerbation.Methods：Forty-eight potients with（COPD）in acute exacedation were randomized into two groups with 24 in each.The control subjects received conventional treatment by westent medicine,and the treatment group were given modified fomule sinitang and xiaoqinglong tang on basis of the treatment preseribed in the controls.Any one course of treatment consisted of 15 days for each group.The patients were observed with regard to the variation of PaO2.PaCO2 and forced expiratory volume at the first second（FEVI）before and after the medication.Results：The two groups were significantly different concerning the obvious effective rate and total effective rate（P〈0.01,P〈0.05）,and the notable difference was seen in PaO2,PaCO2 and FEVI between the two groups（P〈0.05）.Conclusion：Modifed formula sini decocteion and xiaoqinglong decoction are superior to single westerm medicine in treatment of COPD at acute exacerbation.