溃疡性结肠炎患者血清性激素及脂蛋白测定的临床意义

Clinical Significance of Serum Sex Hormones Protein and Lipid Determination in Patients with Ulcerative Colitis

目的:研究溃疡性结肠炎(ulcerative colitis,UC)患者血清蛋白质和脂代谢异常与性激素水平异常的关系。方法:分别测定72例UC组和72例健康对照组血清雌二醇(E2)、睾酮(T)、孕酮(P)、泌乳素(PRL)、促黄体生成素(LH)、促卵泡激素(FSH)及血清总蛋白(TP)、白蛋白(Alb)、球蛋白(G)、白球比(A/G)、总胆固醇(TC)、高密度脂蛋白(HDL-C)、低密度脂蛋白(LDL-C)水平,并对其进行相关分析。性激素测定时对照组采用年龄、性别和卵巢周期与病例组1 1配对的原则。结果:UC患者血清T、LH、FSH、TB、Alb、A/G、TC、LDL-C水平显著低于正常对照组(P<0.01);血清E2、PRL水平显著高于正常对照组(P<0.01)。相关分析表明,UC患者E2与TB、A/G、TC之间存在高度负相关(P<0.01);T与TC、TB之间存在高度正相关(P<0.01)。女性E2与LH、FSH之间无相关性(P>0.05),男性T与LH、FSH之间亦无相关性(P>0.05)。结论:UC患者存在脂蛋白及性激素水平代谢异常,血清性激素水平异常影响患者脂蛋白的水平代谢。测定血清性激素水平可为临床提供新的治疗思路。

Objective To investigate the relationships between changes of serum sex hormones levels and protein-lipid metabolism in patients with ulcerative colitis.Methods Serum levels of estradiol（E2） pregnendione（P）,prolactin（PRL）,luteinizing hormone（LH）,follicle-stimulating hormone（FSH）（with CLIA）,sree testos（T,with RIA） and total-protein（TP）,albumin（Alb）,globulin（G）,albumin/globulinratio（A/G） total-cholesterd（TC）,high densitylipoprotein cholesterols（LDL-C）（with biochemistry were determined in 72 patients） with ulcerative colitis and 72 controls.Results The serum levels of T,LH,FSH,TP,Alb,A/G,TC,LDL-C in patients with ulcerative colitis were significantly 10wer than those in controls（P0.01）,while the serum levels of E2,PRL in patients with ulcerative colitis were significantly higher than those in controls（P0.01）.Correlation analysis showed that the serum levels of E2 were negatively correlated with TP,A/G and TC（P0.01）,on the contrary,the serum levels of T were positively correlated with TP,TC（P0.01）.There were no linear corrlation between LH,FSH and E2 levels in the female sex（P0.05） as well as between LH,FSH and T levels in the male sex（P0.05）.Conclusion The abnormal serum levels of sex hormone might contribate to the derelopment of hypoproteinemia and lowered lipid levels in patients with ulcerative colitis.Treatment with correction of serum sex hormones levels might be beneficial to the patients.