抗甲状腺药物影响Graves’病患者外周血细胞因子水平的表达

Changes of Serum Levels of Some Relevant Cytokine (IL-2,IL-6,TNF-α) After Antithyroid Treatment in Patients with Graves' Disease

目的:研究抗甲状腺药物对Graves’病(GD)患者血清细胞因子水平的影响。方法:用放射免疫分析检测30例GD患者抗甲状腺药物治疗前后血清白细胞介素-2(IL-2)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)水平,30例年龄与性别相匹配的健康者作为正常对照组。结果:GD患者血清IL-6、TNF-α水平显著高于正常对照组(P<0.01),IL-2显著低于正常对照组(P<0.01);抗甲状腺药物治疗,甲状腺功能恢复正常后,IL-2明显升高,与正常对照组比较差异无显著性(P>0.05);IL-6、TNF-α明显低于治疗前(P<0.01),但仍高于正常对照组(P<0.05)。结论:抗甲状腺药物治疗前后血清细胞因子水平的变化可能与发病机制、治疗效果和预后有关。

Objective To study the effect of antithyroid treatment on the changes of serum levels of IL-2,IL-6 and TNF-α in patients with Graves＇ disease.Methods Serum levels of IL-2,IL-6 and TNF-α were measured with RIA in 30 patients with Graves＇ disease（both before and after treatment with antithyroid drug） and 30 controls.Results Before treatment serum levels of IL-6 and TNF-α in the patients were significantly higher than those in controls（P0.01）,while the serum levels of IL-2 were significantly lower（P0.01）.After treatment,serum levels of IL-6 and TNF-α dropped markedly（vs before treatment,P0.01）,but still remained significantly higher than those in controls（P0.05）.The serum IL-2 levels increased greatly and were not much different from those in controls（P0.05）.Conclusion Changes of serum IL-2,IL-6 and TNF-α levels might be important in the pathogenesis of Graves＇ disease.