胸腔积液中CYFRA21-1、NSE、CEA的水平与肺癌组织学分型及TNM分期的关系

Relationship Between the Pleural Effusion Levels of CYFRA21-1,NSE,CEA and Histological Types as well as TNM Stages of the Tumor in Patients with Lung Cancer

目的:探讨胸腔积液中CYFRA21-1、NSE、CEA的水平对肺癌的诊断价值以及与肺癌组织学分型、TNM分期的关系。方法:采用电化学发光法和化学发光法分别检测253例肺癌,39例其他恶性肿瘤以及36例肺结核患者胸腔积液中CYFRA21-1、NSE和CEA的水平。结果:肺癌组胸腔积液中CYFRA21-1、NSE、CEA水平明显高于其他恶性肿瘤组和肺结核组(P<0.01);CYFRA21-1、NSE以及CEA分别在肺鳞癌、小细胞肺癌以及肺腺癌的胸腔积液中表达最高(P分别<0.01、0.01和0.05),并且随TNM分期增加而增高。结论:检测胸腔积液中CYFRA21-1、NSE、CEA水平对肺癌的鉴别诊断、组织学分型以及TNM分期有重要价值。

Objective To investigate the diagnostic value of detection of cytokeratin fragment 19（CYFRA21-1）,neuron specific enolase（NSE）,carcinoembryonic antigen（CEA） in malignant pleural effusion,as well as the relationship between the levels of these tumor markers and the histological types,TNM stages of the tumor in patients with lung cancer.Methods Pleural effusion levels of CYFRA21-1,NSE were detected with electrochemiluminescence immunoassay and CEA were detected with chemiluminescence immunoassay in 328 patients（253 lung cancer,39 other cancers and 36 tuberculosis）.Results The pleural effusion levels of CYFRA21-1,NSE and CEA in patients with lung cancer were significantly higher than those in patients with other cancers and tuberculosis（P0.01）.The levels of CYFRA21-1 in squamous cell carcinoma,NSE in small cell lung cancer（SCLC） and CEA in adenocarcinoma was the highest one respectively（P0.01,0.01 and 0.05 respectively）.The levels of these tumor markers in patients with lung cancer increased as the TNM stages advanced.Conclusion The detections of CYFRA21-1,NSE and CEA in pleural effusion were of differential diagnostic value and might be used to assess histological types and TNM stages of lung cancer.