支气管哮喘患者血清IL-6、TNF-α、IgE检测的临床分析

Clinical Study on Serum IL-6,TNF-α and IgE Contents in Patients with Bronchial Asthma

目的:探讨对支气管哮喘患者进行白细胞介素6(IL-6)、肿瘤坏死因子α(TNF-α)、IgE检测的临床意义。方法:通过观察36例急性支气管哮喘发作期患者(哮喘组)治疗前后血清IL-6、TNF-α、IgE含量的动态变化,并与健康体检者(对照组)比较。结果:哮喘组哮喘发作期患者血清IL-6、TNF-α、IgE含量均明显高于对照组(均P<0.01);哮喘缓解后即刻IL-6、TNF-α、IgE含量均较哮喘发作期有明显下降(均P<0.01);哮喘缓解后14d,IL-6、TNF-α、IgE含量较哮喘缓解后即刻又有明显下降(均P<0.01),但仍较对照组高(均P<0.05)。IL-6、TNF-α含量和IgE含量均呈正相关(r=0.618,P<0.01;r=0.723,P<0.01)。结论:支气管哮喘病情的严重程度与IL-6、TNF-α、IgE含量密切相关,临床可以通过检测IL-6、TNF-α、IgE的含量作为判断支气管哮喘病情严重程度和治疗效果的重要指标。

Objective To study the clinical significance of detecting serum interleukin-6（IL-6）,tumor necrosis factor-α（TNF-α） and IgE contents in patients with bronchial asthma.Methods Serum IL-6,TNF-α and IgE contents were measured with ELISA in 36 patients with bronchial asthma both during acute attack and after treatment（immediate after remission and 14 days later） as well as in 30 controls.Results The serum contents of IL-6,TNF-α and IgE in patients during asthma attack were significantly higher than those in controls（all P0.01）.The levels were significantly decreased immediately after asthma relief（all P0.01）,and then further decreased after 14d（all P0.01）,but still remained higher than those of controls（P0.05）.Significantly positive correlationship was observed between IL-6,TNF-α and IgE levels（r=0.618,P0.01,r=0.723,P0.01）.Conclusion The severity of bronchial asthma is closely related to serum IL-6,TNF-α and IgE content.Therefore,clinical detection of IL-6,TNF-α and IgE levels was useful for assessment of the therapeutic efficacy.