脐血S100B蛋白在早产儿脑损伤中的临床意义及预测价值

Clinical significance and predictive value of umbilical cord serum S100B protein in preterm brain damage

目的研究脐血S100B蛋白在早产儿脑损伤中的临床意义及预测价值。方法对59例孕周<34周的早产儿用酶联免疫吸附试验检测脐血S100B蛋白;将母亲的胎盘胎膜组织行病理学检查,诊断有无绒毛膜羊膜炎;早产儿出生后72h内头颅超声检查,诊断有无脑损伤。结果早产儿脑损伤组脐血S100B蛋白([3.40±1.38)g/L]明显高于无脑损伤组([1.37±1.19)g/L],两者差异有统计学意义(P<0.05)。应用ROC工作曲线进行分析,以脐血S100B蛋白浓度3.18g/L作为临界点,其诊断早产儿脑损伤的灵敏度为81.8%,特异度为89.2%。母亲有绒毛膜羊膜炎、出生体质量<1500g及出生孕周<32周的早产儿脑损伤发生率明显升高。结论脐血S100B蛋白检测是判断34周前早产儿有无宫内脑损伤的客观指标,并且对早产儿脑损伤具有一定的预测价值。

Objective To study Clinical significance and predictive value of umbilical cord serum S 100B protein concentration in preterm brain damage. Methods 59 preterms （〈34 weeks） were involved, and the umbilical cord serum S 100B protein concentrations of preterms were detected by enzyme linked immunosorbent as saay. Maternal chorioamnionitis was determined by histologic examination, and brain damage was diagnosed by ultrasonography. Results Umbilical cord serum S100B protein concentrations in preterm brain damages（3.40±1.39） μg/L were significantly higher than those without brain damages（1.37±1.19 ） μg/L（P〈0.05）. According to ROC curve, the umbilical cord serum S 100B protein concentration 3.18μg/L was used as creteria to diagnose the brain damage. The sensitivity was 81.8%, and the specificity was 89.2%. The incidence of brain damage was higher in those whose mother had chorioamnionitis, birh weight 〈1500 g and birth age 〈32 weeks. Conclusion Umbilical cord serum S100B protein concentration is a useful and objective index for the diagnosis of preterm brain damage, and it is valuable for early diagnosis of preterm brain damage.