软脉灵口服液对血脂和颈动脉粥样硬化斑块的影响

Effects of Ruanmailing Oral Liquid on Blood Lipids and Carotid Atherosclerosis Plaque

目的探讨软脉灵口服液对血脂和颈动脉粥样硬化斑块的影响。方法选择血脂高于正常且有颈动脉粥样硬化斑块的患者60例,随机分为3组,每组20例。软脉灵组口服软脉灵口服液每次10mL,每日3次。辛伐他汀组口服辛伐他汀每次20mg,每日1次。联合治疗组每日同时服用软脉灵口服液和辛伐他汀,用法、用量与单药治疗组相同,3组疗程均为6个月,观察3组患者颈动脉斑块和血脂变化。结果3组治疗后血清总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)水平均有明显降低,高密度脂蛋白胆固醇(HDL-C)水平升高,颈动脉内-中膜厚度缩小,差异均有统计学意义(P<0.05);治疗后软脉灵组和辛伐他汀组血脂水平、颈动脉内-中膜厚度比较无统计学意义(P>0.05);联合治疗组与软脉灵组、辛伐他汀组治疗后比较,血脂水平、颈动脉内-中膜厚度差异均有统计学意义(P<0.05),且软脉灵组未发现不良反应。结论软脉灵能有效改善血脂水平,稳定颈动脉粥样硬化斑块,联合他汀类药物使用疗效更佳,且安全性好。

Objective To investigate the effect of Ruanmailing oral liquid on blood lipids and carotid atherosclerosis plaque. Methods Sixty patients with higher than normal blood lipid and carotid atheroselerosis were randomly divided into three groups： Ruanmailing oral liquid group（n=20） treated with Ruanmailing oral liquid,simvastatin group（n= 20） treated with simvastatin and combined treatment group（n=20） treated with Ruanmailing oral liquid and simvastatin for 6 months. The changes of carotid artery plaque and blood lipid were observed. Results After treatment,the levels of serum total cholesterol（TC） ,triglyeeride （TG）, low - density lipoprotein cholesterol（LDL- C） were significantly decreased, while high- density lipoprotein cholesterol（ HDL- C） level were increased, carotid in tima - media thickning reduced in three groups（P〈0.05）. There was no significant difference in blood lipid levels and carotid intima - media thickning between Ruanmailing oral liquid group and simvastatin group（P〉0.05）. There was significant difference in blood lipid levels and carotid intima- media thickning between combined treatment group and Ruanmailing oral liquid group or simvastatin group（P〈0.05）. There was no adverse reactions in Ruanmailing oral liquid group. Conclusion Ruanmailing oral liquid could improve blood lipid and stabilize carotid atherosclerotie plaque. Ruanmailing oral liquid combined with statins had better efficacy and safety.