丹参多酚酸盐对老年不稳定型心绞痛患者血清细胞因子水平的影响

Effect of Salvianolate on Serum Cytokins Level in Elderly Patients with Unstable Angina Pectoris

目的研究丹参多酚酸盐治疗对老年不稳定型心绞痛(UAP)患者血清细胞因子水平的影响。方法将72例UAP患者随机分为常规治疗组及丹参多酚酸盐治疗组(丹参多酚酸盐组),观察治疗前后血清白细胞介素18(IL-18)、白细胞介素1(IL-1)以及可溶性细胞间黏附分子-1(sICAM-1)水平的变化,并与18名正常对照组作比较。结果UAP患者血清IL-18、IL-1、sICAM-1水平较正常对照组明显升高(P<0.01),常规治疗组治疗后血清IL-18、IL-1较治疗前降低(P<0.05或P<0.01),而在丹参多酚酸盐组IL-18、IL-1、sICAM-1均较治疗前明显降低(P<0.01),且丹参多酚酸盐组治疗后较常规治疗组下降明显(P<0.05或P<0.01)。结论IL-18、IL-1和sICAM-1可能不同程度参与老年不稳定型心绞痛的病理生理进程。丹参多酚酸盐对UAP患者的心血管保护作用与其显著降低IL-18、IL-1以及sICAM-1水平,从而抑制冠脉局部的炎症级联反应有关。

Objective To investigate the effect of salvianolate on the serum cytokins level in elderly patients （pts） with unstable angina pectoris （UAP）. Methods Seventy- two pts were divided randomly into conventional therapy group and salvianolate group. The levels of interleukin - 18 （IL - 18）,interleukin - 1 （IL - 1 ） and intercellular adhesion molecular （ICAM - 1 ） were evaluated by ELISA method before and 2 weeks after therapy. The levels of the cytokins were compared with 18 normal controls. Results The levels of serum IL- 18, IL- 1 and sICAM - 1 in patients with UAP were higher than that in the control group（P〈0.01） and the levels of IL - 18 and IL - 1 were decreased after treatment with conventional therapy（P〈0. 05 or P〈0. 01）. The levels of serum IL- 18 ,IL- 1 and sICAM- 1 were decreased after treatment with salvianolate therapy（P〈0.01）, with more significant effect compared with conventional therapy group（P〈0.05 or P〈0.01）. Conclusion The result suggested that IL - 18, IL - 1 and sICAM - 1 might be involved in the development of unstable angina pectoris. Salvianolate might inhibit the inflammatory injury in coronary artery by decreasing the secretion of IL- 18 ,IL- 1 and sICAM - 1 in the eider pts with UAP.