硫普罗宁治疗抗结核药物性肝损害的临床观察

Clinical observation of tiopronin on treating liver injury caused by antituberculous drugs

目的:探讨硫普罗宁治疗抗结核药物性肝损害的疗效。方法:121例抗结核药物性肝损害患者,随机分为治疗组61例,对照组60例,治疗组给予硫普罗宁注射液0.2 g加入5%葡萄糖注射液250 mL中静脉滴注,每日1次,对照组给予一般护肝药治疗。结果:两组治疗前比较差异无显著性(P>0.05),治疗组与对照组治疗4周后比较差异有显著性(P<0.05);治疗组治疗7,15,30 d,丙氨酸转移酶(ALT)、总胆红素(TBIL)复常率为78.69%,91.8%和100%,对照组治疗7,15,30 d,ALT、TBIL复常率分别为31.67%,71.67%,90%,治疗组ALT、TBIL复常率优于对照组(P<0.01)。结论:硫普罗宁治疗抗结核药物性肝损害效果明显。

Objective：To investigate the efficacy of tiopronin on treating liver injury caused by antituberculous drugs. Methods ： The patients were randomly assigned to two groups, 61 cases were in the treatment group treated with tiopronin, 60 cases in the control group treated with general liver protectant. Results：There was no statistically difference between the treatment group and the control group before treatment （P〉0. 05）. After 4 weeks of treatment ,there were statistically differences between the treatment group and the control group（P〈0.05）. The normalization rate of ALT and TBIL in the treatment group was better than the control group （ P 〈 0 . 0 1 ） . There was 78. 69 %, 91.8% and 100% respectively after 7 d, 15 d and 30 d. Conclusion ：Tiopronin could be used efficiently in the treatment of liver injury caused by antituberculous drugs.