应用欣母沛预防前置胎盘产后出血的临床研究

Clinical study on preventing hemorrhage after cesarean section in placenta previa by using hemabate

目的观察欣母沛预防前置胎盘产后出血的临床疗效。方法选择前置胎盘行剖宫产术的产妇66例,分为观察组和对照组,对照组于剖宫产术中胎儿娩出后即在子宫壁注射缩宫素20 U,并同时予生理盐水500 mL加缩宫素20 U静脉滴注,观察组在上述治疗基础上,同时给予宫壁注射欣母沛250μg。比较两组产后2 h内及24 h内出血量。结果观察组产后2 h内出血量为(258.36±45.5)mL、24 h内出血量为(301.71±49.3)mL,对照组产后2 h内出血量为(398.58±68.6)mL、24 h内出血量为(452.56±52.7)mL,观察组的出血量明显低于对照组(P<0.05)。结论应用欣母沛预防前置胎盘产后出血比缩宫素效果更显著。

Objective To observe the curative effect of hemabate for preventing hemorrhage after cesarean section of women with placenta previa. Methods 66 patients of cesarean section with placenta previa were assigned to two groups：observation group and control group. Control group was injected oxytocin into their uterine corpus immediately after cesarean section and injected oxytocin by intravenous drip simultaneously. Observation group was injected hemabate on the basis of the treatment of control group. The bleeding amounts of 2 hours and 24 hoers after operation were compared. Results The bleeding amounts of 2 hours and 24 hours in observation group were （258.36 ± 45.5 ） mL and（301.71 ±49. 3）mL respectively. The bleeding amounts of 2 hours and 24 hours in control group were（398. 58 ± 68. 6 ）mL and（452.56 ± 52.7 ）mL respectively. The amout of bleeding in observation group was significantly lower than that of the control group（ P 〈 0. 05 ）. Conclusion Hemabate is more effective than oxytocin for preventing hemorrhage after cesarean section of women with placenta previa.