视黄酸对胃癌细胞恶性表型的影响

Effect of Retinoic Acid on the Phenotype of Gastric Cancer Cells

研究ｔ－ＲＡ对胃癌细胞的作用和探讨其作用机理．结果表明：１）ｔ－ＲＡ能够有效地抑制胃癌细胞的生长．２）ｔ－ＲＡ能够降低胃癌细胞在软琼脂中形成集落的能力．３）ｔ－ＲＡ能够降低胃癌细胞的粘附能力．４）ｔ－ＲＡ能够抑制胃癌细胞在裸鼠中形成肿瘤的能力．４）扫描电镜观察显示，经ｔ－ＲＡ处理后，胃癌细胞表面的微绒毛消失．以上结果表明，ｔ－ＲＡ对胃癌细胞的恶性表型有显著的抑制作用．ｔ－ＲＡ可能作为治疗胃癌的有效药物．

In this study, we investigated the role of all trans retinoic acid (t RA) in human gastric cancer cell lines in vitro and in vivo . Our data showed that 1)t RA effectively inhibited the growth of gastric cancer cells. 2) t RA decreased the colony formation ability of gastric cancer cells in solf agar. 3) t RA decreased adhesive ability of gastric cancer cells. 4)t RA supressed the growth of tumor induced by gastric cancer cells in nude mice. 5)Scanning electron microscope showed that microvilli on the surface of gastric cancer cells disappeared after t RA treatment.The results above suggest that t RA can reverse the malignant phenotype of gastric cancer cells. t RA may provide therapeutic possibility for gastric cancer.