生长抑素针对消化性溃疡大出血临床应用

The clinical application of somatostatin in massive hemorrhage of peptic ulcer

目的探讨生长抑素在消化性溃疡大出血的应用,快速、有效、安全地控制消化性溃疡大出血。方法在临床中选取消化性溃疡大出血的病人共78人,其中42人加用生长抑素及禁食,泮托拉唑针、补液、输血、对症、支持治疗,对照组仅禁食,泮托拉唑针、补液、输血、对症、支持治疗。结果生长抑素组:显效36人,有效5人,无效1人;24h止血率为86%,48小时止血率98%。对照组:显效24人,有效8人,无效4人,转外科手术治疗,24h止血率67%,48h止血率89%。结论单用质子泵抑制剂治疗消化性溃疡大出血有良好效果,但仍有部分不能缓解,加用生长抑素后,效果更加显著,极大地减少了手术治疗止血和治疗风险。

Objective：To explore the application of somatostatin in massive hemorrhage of digestive ulcer.Methods：78 patients with massive hemorrhage of digestive ulcer were divided into the experimental group and the control group,42 patients in experiment group were received somatostatin and conventional therapy,and the control group received conventional therapy only.Results：In the experimental group,36 cases had marked effect,5 cases had general effect,only 1 case without effect.The haemostatic rate at 24 hours was 80%,at 48 hours was 98%.While in the control group,24 marked effect,8 with general effects,4 without effect,the haemostatic rate at 24 hours was 67%,at 48 hours was 89%.Conclusion：Somatostatin can greatly improve the effect of proton pump inhibitors.