摘要
目的：研究血管内皮生长因子-C在结直肠癌中的表达,探讨其与淋巴结转移的关系。方法：应用流式细胞学检测80例结直肠癌手术切除标本中VEGF-C的表达。结果：结直肠癌VEGF-C的阳性率为53.8%,与正常粘膜差异有显著性 VEGF-C在淋巴结转移阳性组中的表达与阴性组比较差异有统计学意义（P〈0.05） VEGF-C的表达与Dukes分期密切相关（P〈0.05）,但与年龄、性别、肿瘤的位置、炎细胞浸润无明显相关。结论：VEGF-C的表达可能参与肿瘤淋巴管生成,与结直肠癌淋巴结转移有一定的相关性。
Objective： To study the expression of vascular endothelial growth factor-C in colorectal carcinoma and its relationship with lymph node metastasis. Methods：The expression of VEGF-C protein in colorectal carcinoma tissues obtained from 80 patients who underwent radical resection was detected by FCM. Results：VEGF-C protein was expressed in 53.8% of patients. Its expression was more frequently detected in tumors with lymph node metastasis than in those without lymph node metastasis （P〈0.05）,and there was significant correlation between its expression and lymphatic invasion, Duke＇s staging （P〈O.05）. However, there was no significant correlation between its expression and the age, gender, tumor location, inflammation cell invasion. Conclusion：The expression of VEGF-C is closely related to lymph node metastasis, and it is likely to take part in tumor lymphangiogenesis.
