急性心梗合并糖尿病患者血Hcyhs-CRP的相关性研究

The Investigation on Homocysteine and High-Sensitive C-reactive Protein in Acute Myocardial Infarction Patients with Diabetes Mellitus

目的:探讨急性心肌梗死合并糖尿病患者血Hcy、hs-CRP水平的变化及其临床意义。方法:急性心肌梗死合并糖尿病患者30例(DM组)及同期住院非糖尿病的急性心肌梗死患者30例(非DM组)为研究对象,另选择同期住院的稳定性心绞痛患者30例为对照组。所有患者均检测血Hcy、hs-CRP浓度,经正规治疗并随访3个月,观察再发心绞痛、再发非致死性心肌梗死及心脏性死亡的发生率,分组比较标志物浓度及其与患者预后的关系。结果:DM组、非DM组血Hcy与hs-CRP浓度均较对照组高(P<0.01),另外DM组二者浓度均较非DM组高(P<0.05),DM组血Hcy与hs-CRP浓度呈正相关。在随访中,DM组与非DM组再发心绞痛,再发心肌梗死及心脏性死亡的发生率均高于对照组(P<0.01),而DM组又高于非DM组(P<0.05)。结论:血Hcy、hs-CRP浓度是评价急性心肌梗死患者预后的重要指标且与患者病情呈正相关。

Objective：To explore the levels of plasma homocysteine（Hcy） and high-sensitive C-reactive Protein（hs-CRP） in acute myocardial infarction patients with diabetes mellitus and its,clinical significance.Methods：Observing and comparing 3 groups of in patients at the same time.DM Group-30 patients with acute myocardial infarction and diabetes mellitus、Non-DM Group-30 acute myocardial infarction patients without diabetes mellitus are studied and compared with the control group-30 patients with stable angina.All the subjects had been systematically treated and monitored for three months afterwards.The levels of Hcy and hs-CRP of the subjects had been measured and the recurrence rate of angina myocardial infarction and cardiogenic death had been counted.Hcy and hs-CRP levels of patients in different groups was compared and the relationship among the the recurrence patients was analyzed.Result：Hcy and hs-CRP levels of patients in DM group and Non-DM group are higher than that of patients in the control group（P〈0.01）;Hcy and hs-CRP levels of patients in DM group are higher than that of patients in Non-DM group（P〈0.05）;there is a positive correlation between the level of Hcy and the level of hs-CRP of patients in DM group.In follow-up visit,the ratio of recurrence patients in angina,recurrence myocardial infarction and cardiogenic death of patients in DM group and Non-DM group is higher than that of patients in control group.Conclusion：The levels of Hcy and hs-CRP are key indicators in the prognostic evaluation of patients with acute myocardial infarction patients and have a positive correlation with patient＇s condition.