替米沙坦与胺碘酮联合治疗阵发性心房颤动121例临床观察

Clinical Observations of Telmisartan Combination Therapy with Amiodarone in Patients with Paroxysmal Atrial Fibrillation

目的:探讨替米沙坦与小剂量胺碘酮联用治疗心功能正常的阵发性心房颤动维持窦性心律的长期疗效。方法:将121例阵发性房颤随机分为胺碘酮组(A组,n=61)、胺碘酮+替米沙坦组(B组,n=60),治疗随访时间为1.5年,比较两组治疗后6、12、18、24个月的窦性心律维持率以及治疗前、治疗后的左心房内径。结果:治疗12个月后,A组左心房内径大于B组(P<0.05),治疗12个月后,A组窦性心律的维持率明显低于B组(P<0.05)。结论:胺碘酮与替米沙坦配伍治疗阵发性房颤,维持窦性心律的疗效显著优于单用胺碘酮,并能抑制左心房的扩大。

Objective：To evaluate the clinical effieacy of Telmisartan in combination with Amiodarone on maintenance of sinus rhythm in patients with idiopathic paroxysmal atrial fibrillation（PAF）.Methods：One hundred and twenty-one patients with idiopathic PAF were included in the study and randomly divided into two groups：group A was treated with amiodarone alone,group B was treated with amiodarone and telmisartan in combination.The left atrial diameter（LAD）was measured with transthoracic echocardiogram at before and after 6、12、18 and 24month of treatment.The duration of observation was up to one and half years and the primary end point of the study was the first recurrence of AF.Results：After 12 months,LAD in group A was significantly larger than that in group B（P〈0.05）,the sinus rhythm maintenance of group A was lower significantly than that of group B.At the end of the study,the maintenance of sinus rhythm in groupB was higher significantly than that in group A.Conclusion：The results of this study suggest that the combination of amiodarone with telmisartan are more effective than amiodarone alone in sinus rhythm maintenance for idiopathic PAF,and may restrain the enlargement of the left atrium.