大鼠严重烧伤早期牛磺酸对心肌的保护效应

Protective Effect of Taurine on Rat's Myocardium in Early Stage of Rat Severe Burn

目的:明确牛磺酸对烧伤后心肌组织具有保护作用。方法:健康雄性S-D大鼠32只,随机分为正常组,假伤组、烧伤组和牛磺酸处理组,其中烧伤组和牛磺酸处理致成30%TBSA III°烧伤,于伤后6h以多道生理信号采集处理系统检测心肌力学指标等(SDP,DBP,LVSP,LVEDP,+LVdp/dtmax,-LVdp/dtmax)。结果:烧伤后6h LVSP,+LVdp/dtmax,-LVdp/dtmax较对照组均明显降低(P<0.01),LVEDP明显增高(P<0.01;而加入牛磺酸后均较烧伤组明显减轻。结论:牛磺酸可以明显改善烧伤后心肌功能,发挥其保护效应。

Objective：To clarify the protective effects of taurine in myocardium subjected to severe burn.Methods：32 SD neonatal rats were randomized to normal group,sham injury group,burn group and taurine-treated groups.The study was carried out using a model of 30%TBSA of full-thickness burns in SD rats.The myocardiac mechanics indexes（SDP,DBP,LVSP,LVEDP, ＋LVdp/dtmax,-LVdp/dtmax）of all the rats were recorded by Multiple Channel Physiological Signal Collecting and Processing System. Results：The LVSP,＋LVdp/dtmax and-LVdp/dtmax decreased significantly（P〈0.01）,LVED increased.However,when rats were subjected to Taurine,the degree of myocardium damage was decreased significantly（P〈0.01）.Conclusion：Taurine can protect rat＇s myocardium in the early stage of rat severe burn.