内蒙古地区汉族多囊卵巢综合征患者临床特征研究

Analysis of Clinical Data in Inner Mongolia Chinese Women with Polycystic Ovary Syndrome

目的:分析总结多囊卵巢综合征(Polycystic ovary syndrome,PCOS)合并不育患者的临床及内分泌代谢特征,为PCOS的临床诊治提供依据。方法:回顾性分析120例PCOS患者(其中肥胖型73例,非肥胖型47例)的临床特征及内分泌、空腹血糖(FPG)、空腹胰岛素(FINS)等检查指标。用稳态模型胰岛素抵抗指数(HOMA-IR)、稳态模型胰岛素分泌指数(HOMA-IS)、空腹胰岛素敏感指数(ISI)评估胰岛素敏感性。结果:两组患者睾酮(T)、黄体生成素(LH)、卵泡刺激素(FSH)、LH/FSH无显著差别。肥胖组的FPG和FINS水平明显高于非肥胖组。两组胰岛素抵抗(IR)发生率分别为86.30%和51.06%。肥胖组的IR、ISI均明显高于非肥胖组。结论:PCOS患者肥胖发生率较高,肥胖型PCOS患者较非肥胖型患者存在更严重的代谢紊乱。减重、改善IR不仅可以改善PCOS不育情况,更是预防2型糖尿病、心血管疾病等远期并发症的关键。

Objective：To provide basis for the clinical diagnose and treatment of polycystic ovary syndrome（PCOS）.Methods： One hundred and twenty PCOS patients were included in this retrospective study.They were divided into obese group（n=73）and non-obese group（n=47）according to body mass index（BMI）and waist hip ratio（WHR）.Clinical presentations,serum hormonal levels, glucose levels and insulin levels were reviewed.Result：FSH did not differ significantly between the two groups,nor did LH or LH/FSH, T,or HOMA-IS with the exception of significantly higher FBG,FINS,HOMA-IR（marker for insulin resistance）and ISI in the obese PCOS group（P0.05）.Conclusion：The prevalence of obesity is higher in PCOS than cornmon person.The state of obesity has a positive relation with insulin resistance（IR）.Obese women with PCOS have a high prevalence of IR,compared with non-obese controls. Losing weight is the primary therapy for PCOS.