同种异体心脏移植中急性排斥反应免疫学机制及进展

Progress of the Immunological Mechanism of Acute Rejection in Allogeneic Cardiac Transplantation

目前,同种异体心脏移植已成为一种应用于临床治疗终末期心脏病的较为有效方法。急性排斥反应是目前同种异体心脏移植中最常见的一种移植免疫排斥反应,是心脏移植第一年失败的主要原因。因此,解决和研究心脏移植中急性排斥反应及其发生机制,己成为当今临床移植研究的紧迫课题。现就其免疫学机制,目前研究现状及进展等作一综述。

At present,allogeneic heart transplantation has become a kind of more effective manner which used in clinical treatment of end-stage heart.Acute rejection of allogenic heart transplantation is currently the most common form of allograft rejection and is the main reason for the failure of heart transplantation during the first year.Thus,the solution and study of acute rejection in heart transplantation and its mechanism,has become the urgent task for the study of clinical transplantation.This article discussed its immunological mechanisms,status and progress of current research.