正交实验法优选妇骨肽软胶囊提取工艺

Optimum the Extraction Process for Fu Gutai soft gelatin capsule by Ortho gonal Design

目的:优选妇骨肽软胶囊最佳提取工艺。方法:选择溶媒用量、提取时间、提取次数、乙醇浓度为考察因素,每个因素设计三个水平,采用L9(34)正交设计法进行实验,以提取液中柚皮苷转移率和浸膏得率为指标对妇骨肽软胶囊提取工艺进行优化筛选。结果:妇骨肽软胶囊最佳提取工艺为用60%乙醇提取3次,每次加溶媒10倍量,每次提取1.5 h。结论:确定的提取工艺稳定、经济、可行。

Objective： To explore the optimal extraction technique of Fu Gutai soft gelatin capsule. Method ： Choose four factors, ethanol consumption, extraction time, extraction times, ethanol concentration, and each factor have three levels. The ortho gonal design is used to optimize extraction process of FuGutai soft gelatin capsule with the content of Naringi,extracta sieca yield as markers. Result：The result shows that the optimum extraction condition is：adding 10 times of 60% ethanol boiling for 1.5 hours each time, extracting three times in all. Conclusion ：The optimized process is stable,economic and feasible.