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APPL1与胰岛素抵抗 被引量：2

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摘要 Adaptor protein containing PH domain，PTB domain and leucine zipper motif 1（APPL1）是一种具有多个功能结构域的细胞内转接蛋白，包含PH结构域、PTB结构域以及亮氨酸拉链基序。研究发现，APPL1可与多个蛋白结合，参与细胞内多条信号转导通路，与前列腺癌、结肠癌、神经系统相关疾病以及排卵等过程有关。
作者 朱云霞 王琛 贾伟平
机构地区 上海交通大学附属第六人民医院
出处 《上海医学》 CAS CSCD 北大核心 2009年第12期1136-1138,共3页 Shanghai Medical Journal
基金 上海市浦江人才计划(07pj14062) 国家教育部新教师基金项目(20070248098) 上海市糖尿病重点实验室建设项目(08DZ2230200) 国家973重点基础研究发展计划项目(2006CB503901)
关键词 胰岛素抵抗 PH结构域 PROTEIN 信号转导通路 蛋白结合 亮氨酸拉链 前列腺癌 相关疾病
分类号 R587.1 [医药卫生—内分泌] R392.11 [医药卫生—免疫学]
  • 相关文献

参考文献15

  • 1Mao X, Kikani C K, Rioias R A, et al. APPL1 binds to adiponectin receptors and mediates adiponectin signalling and function. Nat Cell Biol, 2006, 8: 516-523.
  • 2Mitsuuchi Y, Johnson S W, Sonoda G, et al. Identification of a chromosome 3p14. 3-21. 1 gene, APPL, encoding an adaptor molecule that interacts with the oncoprotein-serine/ threonine kinase AKT2. Oncogene, 1999, 18: 4891-4898.
  • 3Liu J, Yao F, Wu R, et al. Mediation of the DCC apoptotic signal by DIP13 alpha. J Biol Chem, 2002, 277: 26281- 26285.
  • 4Staiger H, Machicao F, Machann J, et al. Genetic variation within the APPL locus is not associated with metabolic or inflammatory traits in a healthy White population. Diabet Med, 2007, 24: 817-822.
  • 5Cheng K K, Lam K S, Wang Y, et al. Adiponectin-induced endothelial nitric oxide synthase activation and nitric oxide production are mediated by APPL1 in endothelial cells. Diabetes, 2007, 56: 1387-1394.
  • 6Chial H J, Wu R, Ustach C V, et al. Membrane targeting by APPL1 and APPL2: dynamic scaffolds that oligomerize and bind phospboinositides. Traffic, 2008, 9: 215-229.
  • 7Zhu G, Chen J, Liu J, et al. Structure of the APPL1 BAR- PH domain and characterization of its interaction with RahS. EMBO J, 2007, 26, 3484-3493.
  • 8Miaczynska M, Christoforidis S, Giner A, et al. APPL proteins link Rab5 to nuclear signal transduction via an endosomal compartment. Cell, 2004, 116 : 445-456.
  • 9Kadowaki T, Yamauchi T, Kubota N, et al. Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome. J Clin Invest, 2006, 116: 1784-1792.
  • 10Saito T, Jones C C, Huang S, et al. The interaction of Akt with APPL1 is required for insulin-stimulated Glut4 translocation. J Biol Chem, 2007, 282: 32280-32287.

二级参考文献23

  • 1陈蕾,项坤三,贾伟平,陆俊茜,包玉倩,陆惠娟.血清脂联素浓度与体脂分布及葡萄糖钳夹试验中胰岛素敏感性的关系[J].中华医学杂志,2005,85(21):1456-1459. 被引量：10
  • 2汝颖,马猛,马腾,王长江,王佑民,章秋,陈明卫.脂联素基因SNP276多态性与2型糖尿病易感性及胰岛素敏感性的关联[J].中华医学遗传学杂志,2005,22(6):698-701. 被引量：18
  • 3胡承,贾伟平,张蓉,王从容,方启晨,马晓静,陆俊茜,徐靖,项坤三.脂联素受体1基因-3881T／C多态位点与中国人糖代谢的关系[J].中华医学遗传学杂志,2007,24(1):27-30. 被引量：3
  • 4DeFronzo RA, Ferrannini E. Insulin resistance. A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease. Diabetes Care, 1991,14 : 173-194.
  • 5Berg AH, Combs TP, Scherer PE. ACRP30/adiponectin: an adipokine regulating glucose and lipid metabolism. Trends Endocrinol Metab, 2002,13:84-89.
  • 6Kadowaki T, Yamauchi T. Adiponectin and adiponectin receptors. Endocr Rev,2005,26:439-451.
  • 7Lafontan M, Viguerie N. Role of adipokines in the control of energy metabolism: focus on adiponectin. Curr Opin Pharmacol, 2006,6:580-585.
  • 8Mao X, Kikani CK, Riojas RA, et al. APPL1 binds to adiponectin receptors and mediates adiponectin signalling and function. Nat Cell Biol,2006,8:516-523.
  • 9Mitsuuchi Y, Johnson SW, Sonoda G, et al. Identification of a chromosome 3p14.3-21.1 gene, APPL, encoding an adaptor molecule that interacts with the oncoprotein-serine/threonine kinase AKT2. Oncogene, 1999,18:4891-4898.
  • 10Staiger H, Machicao F, Machann J, et al. Genetic variation within the APPL locus is not associated with metabolic or inflammatory traits in a healthy white population. Diabet Med, 2007,24:817-822.

共引文献7

同被引文献29

  • 1成扬,平键,徐列明,刘成,谭英姿,陈高峰.姜黄素上调PPARγ抑制肝星状细胞活化标志表达的研究[J].中国实用内科杂志：临床前沿版,2006,26(12):1937-1940. 被引量：17
  • 2Li S, Shin H J, Ding EL, et al. Adiponectin levels and risk oftype 2 diabetes: a systematic review and meta-anaiysis[ J]. JA-MA ,2009,302(2) :179 -88.
  • 3Leto D,Saltiel A R. Regulation of glucose transport by insulin : traf-fic control of GLUT4[ J]. Nat Rev Mol Cell Biol,2012,13 (6) :383.
  • 4Liu Y, Chewchuk S,Lavigne C, et al. Functional significance ofskeletal muscle adiponectin production,changes in animal modelsof obesity and diabetes,and regulation by rosiglitazone treatment[J]. Am J Physiol Endocrinol Metab, 2009,297(3) : E657 -64.
  • 5Saito T, Jones C C, Huang S, et al. The interaction of Akt withAPPL1 is required for insulin-stimulated GLUT4 translocation [ J ].J Biol Chem,2007, 282(44) :32280 -7.
  • 6Mao X, Kikani C K, Riojas R A, et al. APPL1 binds to adipone-ctin receptors and mediates adiponectin signalling and function[J]. Nat Cell Biol, 2006,8(5) :516 -23.
  • 7Lehnen A M,Leguisamo N M, Pinto G H, et al. Exercise-stimu-lated GLUT4 expression is similar in normotensive and hyperten-sive rats[ J]. Horm Metab Res,2011,43(4) :231 -5.
  • 8MAO X. KIKANI C K. RIO] AS R A. et al. APPU binds to adiponectin receptors and mediates adiponectin signalling and function[J]. Nat Cell Biol , 2006. 8(5): 516-523.
  • 9CHAPMAN H. WACLAW R R. PEl Z. et al. The homeobox gene Gsx2 controls the timing of oligodendroglial fate specification in mouse lateral ganglionic eminence progenitors[J]. Development. 2013. 140(11): 2289-2298.
  • 10LI L, LI X, ZHU v, et al. Growth receptor binding protein 10 inhibits glucose-stimulated insulin release from pancreatic -cells associated with suppression of the insulin/insulin-like growth Iactor-I signalling pathway[J]. Clin Exp Pharmacol Physiol , 2013, 40(12): 841-847.

引证文献2

二级引证文献2

上海医学
2009年 第12期

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