肿瘤特异性启动子驱动的RNA干扰与肿瘤基因靶向治疗

RNA interference driven by tumor-specific promoters and targeted therapy of tumor

应用肿瘤特异性启动子如甲胎蛋白启动子、人端粒酶逆转录酶启动子、存活素启动子等，驱动RNA干扰（RNAi）在肿瘤组织中发挥靶向治疗效应。该方法把肿瘤启动子的特异性和RNAi的高效性有机结合起来，可以实现对肿瘤组织的特异、高效杀伤作用。肿瘤特异性启动子驱动的RNAi在肿瘤基因靶向治疗中发挥重要作用。

RNA interference driven by tumor specific promoters has targeted therapeutic effect only in tumor tissue, it is a new method in tumor gene therapy, such as alpha-fetoprotein promoter, human telomerase re- verse transcriptase promoter, survivin promoter and etc. This method binds specificity of tumor promoter and high effects of RNAi, and can realize specific and highly killing effects in tumor tissue. RNAi driven by tumor specific promoters plays an important role in tumor oncogene targeted therapy.