三叶因子1与胃癌

Trefoil factor 1 and gastric cancer

三叶因子1（TFF1）主要表达于胃肠道黏膜，在胃癌组织中的表达改变具有抑癌和促癌双重作用，涉及到改变基因结构、延迟细胞周期转变、信号转导、抑制细胞凋亡及与环氧合酶-2相互作用等方面，但其具体作用机制尚不清楚。TFF1在胃癌的诊断和治疗方面的研究取得了一定进展。

Trefoil factor 1 （ TFF1 ） is mainly expressed in the mucosa lining the gastrointestinal tract. Changes of its expression in gastric cancer tissue play dual roles of carcinogenesis and anti-cancer action involved in modifying the genetic structure, delaying the transition of cell cycle, signal transduction, suppressing cell apoptosis and interaction with cyclooxygenase-2, but the specific mechanism is still unclear. Certain advances have been made on the diagnosis and therapy of gastric cancer.