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南海红树林内生真菌ZSU-H19代谢产物研究 被引量:3

Metabolites of Mangrove Endophytic Fungus ZSU-H19 from South China Sea
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摘要 对南海红树林内生真菌ZSU-H19代谢产物进行研究,从菌体中分离得到6个化合物,现代谱学方法分析表明它们是:ophioglonin(1)、ophioglonin-7-O-β-D-glucopyranoside(2)、吲哚-3-乙酸(3)、尿囊素(4)、环(酪氨酰-亮氨酸)(5)、环(色氨酰-丙氨酸)(6),其中1和2为首次从微生物中分离发现。初步药理活性显示,1和2对人鼻咽癌细胞株KB显示微弱抑制活性,IC50分别为3.0×10-2和1.0×10-2g/L。 Six compounds, ophioglonin (1), ophioglonin-7-O-β-D-glucopyranoside (2), indole-3-acetic acid (3),allantoin (4),cyclo-(Tyr-Leu) (5),and cyclo-(Trp-Ala) (6)were isolated from the mangrove endophytic fungus ZSU-H19 from the South China Sea. Their structures were elucidated by spectral data. Compound 1 and 2 were both isolated from microorganism for the first time. In the preliminary bioassay,1 and 2 show weak inhibitory activity on the KB cell line with ICs0values of 3.0×10-2and 1.0 × 10-2 g/L,respectively.
出处 《广西师范大学学报(自然科学版)》 CAS 北大核心 2009年第4期57-60,共4页 Journal of Guangxi Normal University:Natural Science Edition
基金 国家自然科学基金资助项目(20072058,20572136) 广西自然科学基金资助项目(0832081) 广西民族大学科学研究基金资助项目(200702YJ18)
关键词 红树林内生真菌 代谢产物ZSU—H19 ophioglonin 抗肿瘤活性 mangrove endophytic fungus metabolites ZSU-H 19 ophioglonin antitumor activity
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参考文献11

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二级参考文献21

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