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VEGF的研究进展及其在妇科肿瘤中的应用 被引量：5

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摘要 恶性肿瘤的发生发展是多因素、多阶段的复杂过程，其中肿瘤血管生成是肿瘤生长、浸润和转移的关键因素。血管内皮生长因子（VEGF）是目前已知的直接刺激血管内皮细胞增殖作用最强最特异的因子，具有调节血管及淋巴管的生理功能。
作者 穆彦如(综述) 谢凯(审校)
机构地区 哈尔滨医科大学附属肿瘤医院
出处 《实用肿瘤学杂志》 CAS 2010年第1期90-92,共3页 Practical Oncology Journal
关键词 VEGF 子宫肌瘤 宫颈癌 子宫内膜癌 卵巢癌
分类号 R737.2 [医药卫生—肿瘤] R392.11 [医药卫生—免疫学]
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参考文献24

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  • 3Endo A, Fukuhara S, Masuda M, et al. Selective inhibition of vascular endothelial growth factor receptor - 2 ( VEGFR - 2 ) identifies a central role for VEGFR -2 in human aortic endothelial cell responses to VEGF [ J ]. J Recept Signal Transduct Res,2003,23 ( 1 ) :239 - 254.
  • 4Tang GX, Liu GX. Hypoxia - inducible factor 1 mediated expression of hypoxia - induced vascular endothelial growth factor in human bone marrow stromal cells which is involved in MAP kinase and phosphatidylinositol 3 - kinase signaling [J]. Blood 2005,106(11) :651 -652.
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二级参考文献78

共引文献70

同被引文献92

  • 1曾瑄,王鹏,武莎斐,高洁,梁智勇,刘彤华.结直肠癌EGFR和HER2蛋白表达及其基因拷贝数分析[J].中华病理学杂志,2007,36(7):447-452. 被引量：8
  • 2Koukourakis MI, Limberis V, Tentes I, et al. Serum VEGF levels and tissue activation of VEGFR2/KDR receptors in patients with breast and gynecologic cancer[J]. Cytokine, 2011, 53(3):370-375.
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  • 8Capp C, Wajner SM, Siqueira DR, et al. Increased expres- sion of vascular endothelial growth factor and its recep- tors, VEGFR-1 and VEGFR-2, in medullary thyroid car- cinoma[J]. Thyroid, 2010, 20(8):863-871.
  • 9Klasa-Mazurkiewicz D, Jarzab M, Milczek T, et al. Clini- cal significance of VEGFR-2 and VEGFR-3 expression in ovarian cancer patients[J]. Pol J Pathol, 2011, 62(1):31- 40.
  • 10Lang SA, Brecht I, Moser C. Dual inhibition of Raf and VEGFR2 reduces growth and vascularization of hepatocel- lular carcinoma in an experimental model[J]. Langenbecks Arch Surg, 2008, 393(3):333-341.

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实用肿瘤学杂志
2010年 第1期

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