藏药佐太中的汞在大鼠体内吸收和排泄的初步研究

Preliminary Study on the Absorption and Excretion of Mercury in Tibetan Medicine Zuotai in Rats

目的以藏药佐太主要成分汞为研究对象,初步探讨其在大鼠体内的吸收和排泄情况。方法采用微波消解技术和原子荧光光度计测定血清、肝脏组织、肾脏组织、尿液和粪便中的汞含量。结果实验1组和实验2组大鼠分别连续给予佐太7 d和21 d后,血清中汞含量较低,肾脏组织中汞含量显著增多;实验1组大鼠肝脏组织中汞含量显著增多,但实验2组显著减少;实验组大鼠尿液中检测到的汞较少,粪便中检测到大量的汞。结论佐太中的汞在大鼠体内吸收较少,主要通过粪便排出体外,长期使用在肾脏有蓄积现象。

Objective To study the absorption and excretion of mercury in Tibetan medicine Zuotai in rats. Methods The mercury content in serum ,hepatic tissue, kidney tissue, urine and feces were determined by microwave digestion technique and atomic fluorescence, spectrometer. Results After the first and second groups of experimental rats were respectively administered Zuotai for 7 days and 21 days, the mercury contents in serum were lowered, and the mercury contents in kidney tissue were significantly increased. The mercury content of hepatic tissue was significantly increased in the first experimental group, but significantly decreased in the second experimental group. There was a little mercury in the urine of experimental rats, but a great deal of mercury was determined in the feces. Conclusion The result demonstrated that only a little mercury in Zuotai was absorbed in rats, and most of them was excreted to the environment with feces. The accumulation for mercury was detected in rats after long time and repetitive Zuotai administration.