摘要
目的研究三七皂苷R1在大鼠体内的代谢情况,阐述三七皂苷R1在大鼠体内的代谢产物。方法以三七皂苷R1的微生物转化产物为对照品;采用LC-ESI-MS/MS方法,检测大鼠体内的代谢产物。结果在大鼠体内共检测到8个代谢产物,并利用对照品鉴定了它们的结构分别为:20(S)-三七皂苷R2,20(R)-三七皂苷R2,20(S)-人参皂苷Rh1,20(R)-人参皂苷Rh1,人参皂苷Rh4,原人参三醇,人参皂苷F1和3β,12β-二醇达玛烷-E-20(22),24-二烯-6-O-β-D-木糖-(1→2)-β-D-葡萄糖苷。结论三七皂苷R1在大鼠体内的代谢产物较多,且与微生物转化产物具有很强的相似性。
Objective To investigate the metabolites of notoginsenoside R1 in rats. Methods The microbial transformation metabolites of notoginsenoside R1 were used as standard references. LC - ESI - MS/MS analysis was used in the metabolism studies of notoginsenoside R1 in rats. Results The structures of eight metabolites of notoginsenoside R1 in rat feces were identified by comparison with the reference standards separated from biotransformation. Their structures were identified as 20 （S） -notoginsenoside R2,20（R） - notoginsenoside R2, 20（S） - ginsenoside Rh1 , 20（R） - ginsenoside Rh1 , ginsenoside Rh4, protopanaxatriol, ginsenoside F1 and 313, 12 β - dihydroxydammar - E - 20 （22） - 24 - diene - 6 - 0 - β - D - xylopyranosyl - （ 1→2 ） - β - D - glucopyranoside. Conclusion Notoginsenoside R1 is extensively metabolized in rat and has the same metabolic pathway with microorganisms to some extent.
出处
《时珍国医国药》
CAS
CSCD
北大核心
2010年第2期485-487,共3页
Lishizhen Medicine and Materia Medica Research
