盐酸戊乙奎醚治疗急性重度有机磷农药中毒疗效观察

Investigate the penehyclidine hydrochloride in acute severe organophosphorus pesticide poisoning rescue efficacy

目的探讨盐酸戊乙奎醚对急性重度有机磷农药中毒的抢救疗效观察。方法将41例急性重度有机磷农药中毒患者随机分为治疗组和对照组，时照组按传统方法使用阿托品、氯磷定、机械通气等治疗。治疗组采用盐酸戊乙奎醚、氯磷定、机械通气联合治疗。比较两组治愈率、病死率、呼衰发生率、使用呼吸机天数、住院时间、不良反应发生率。结果治疗组在治愈率、病死率、呼衰发生率指标均优于对照组，但差异无统计学意义（P〉0．05），而治疗组在呼吸机使用天数、住院时间、不良反应发生率方面均明显优于对照组，差异有统计学意义（P〈0．01）。结论盐酸戊乙奎醚抢救急性重度有机磷农药中毒疗效确切、显著、不良反应少，是取代阿托品抢救急性重度有机磷农药中毒的理想药物。

Objective To investigate penehyclidine hydrochloride in acute severe organophosphorus pesticide poisoning rescue efficacy. Methods 41 cases of severe acute organophosphorus pesticide poisoning were randomly divided into treatment group and control group,the control group according to the traditional ways to use atropine, PAM, mechanical ventilation and other treatment. The treatment group were treated with penehyclidine hydrochloride, PAM, mechanical ventilation combination therapy. Compared two groups of cure rate, mortality rate, incidence of respiratory failure, the use of ventilator days, length of stay, incidence of adverse reactions. Results The treatment group in the cure rate, mortality rate, incidence of respiratory failure indicators are better than the control group, but the difference was not statistically significant（ P 〉 0.05 ）, while the treatment group asine a breathing machine days, hospitalization time, incidence of adverse aeactions were significantly better than the control group, the difference was statistically significant（ P 〈 0.01 ）. Conclusion Penehyclidine hydrochloride in acute severe organophosphorus pesticide poisoning curative effect,significantly, fewer adverse reactions,is to replace the atropine, rescue of acute severe organophosphrus pesticide＂ poisoning an ideal drug.