复方白芨灌肠液治疗重型溃疡性结肠炎患者的临床观察及社区应用前景

Compound Baiji Enema for Patients with Severe Ulcerative Colitis:Clinical observation and its prospect of application in community

目的探讨复方白芨灌肠液对重型溃疡性结肠炎患者的治疗效果及社区应用前景。方法将符合入选标准的46例重型溃疡性结肠炎患者随机分为两组,观察组、对照组各23例,均给予抗炎、抑制免疫反应治疗,观察组在此基础上加用复方白芨灌肠液灌肠治疗,观察并比较两组患者治疗前后的临床表现、结肠镜表现、粪便常规及C-反应蛋白、血沉等指标的变化。结果治疗后两组患者的临床严重程度、结肠镜表现、粪便常规、C-反应蛋白及血沉水平比较,差异均有统计学意义(P<0.05);两组患者的疗效比较,差异亦有统计学意义(P<0.05)。结论复方白芨灌肠液可以有效降低重型溃疡性结肠炎患者的C-反应蛋白、血沉水平,并能较好改善临床症状、结肠镜表现、粪便常规,治疗效果显著,为社区合理、安全、有效防治该病提供了实践基础。

Objective To investigate the effect of Compound Baiji Enema（CBE）on patients with severe ulcerative colitis（SUC）and its prospect of application in community.Methods Totally 46 SUC patients who were consistent with the standards of recruitment were randomly divided as trial group and control group,with 23 in each.All the patients were given anti-inflammatory and immunosuppressant therapy,and the patients in the trial group were given additional CBE therapy.Then the changes of clinical presentations,conventional colonoscopy,routine stool examination,C-reactive protein,and erythrocyte sedimentation rate of the patients in the two groups were observed before and after the treatment.Results After treatment the there appeared significant differences between the two groups in clinical severity,colonoscopy,stool examination,C-reactive protein,and erythrocyte sedimentation rate（P0.05）.And the clinical effect was better in the trial group than in the control group（P0.05）.Conclusion The compound Baiji enema can reduce the levels of C-reactive protein and erythrocyte sedimentation rate for SUC patients,and improve their clinical symptoms,colonoscopic presentation,stool findings.It provides a practical basis in community for reasonable,safe and effective control of this disease.