嗜麦芽寡养单胞菌的临床分布及耐药性分析

Clinical Distribution of Stenotrophomonas Maltophilia and Its Drug Resistance

目的了解嗜麦芽寡养单胞菌的标本来源、临床分布及耐药状况。方法选择2008年我院收治的50例嗜麦芽寡养单胞菌感染患者,共分离出60株嗜麦芽寡养单胞菌。采用API staph鉴定系统和K-B琼脂扩散法,对分离的60株嗜麦芽寡养单胞菌进行鉴定和药敏试验。结果嗜麦芽寡养单胞菌主要来源于痰标本,占81.7%(49/60);科室分布主要分离自ICU(35.0%,21/60)和呼吸内科(25.0%,15/60)。该菌对左氧氟沙星、米诺环素、环丙沙星的耐药率较低,分别为7.1%、20.8%、24.1%,对其他抗菌药物的耐药率均较高。结论嗜麦芽寡养单胞菌具有高度和多重耐药性,临床抗感染治疗应根据药敏试验结果选用敏感药物。

Objective To study the clinical distribution of Stenotrophomonas maltophilia（SM） and its drug resistance.Methods A total of 60 SM trains were isolated from 50 SM infected patients admitted to our hospital in 2008.API staph system and K-B agar diffusion method were used to identify the isolated SM and to perform drug susceptibility testing.Results Sputum was the main resource of SM specimens,accounting for 81.7%（49/60）,isolated mainly from ICU（35.0%,21/60）and Department of Respiratory Medicine（25.0%,15/60）.Its resistance to levofloxacin,minocycline,ciprofloxacin was relatively low（7.1%,20.8% and 24.1% respectively）,but higher to other antimicrobial agents.Conclusion SM has high and multiple drug resistance.Drugs should be chosen based on sensitivity test results in clinical anti-infective therapy.