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脐血干细胞移植治疗血管性痴呆 被引量:5

Umbilical Cord blood Stem Cell Transplantation in Treatment of Vascular Dementia
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摘要 血管性痴呆(vascular dementia,VD)是由缺血或出血性脑血管病以及全脑缺血、缺氧引起的认知障碍。传统药物治疗效果欠佳,脐血干细胞具备很强的增殖和分化能力,在一定条件下可分化为神经元,进而起到治疗VD的作用。脐血干细胞治疗VD研究已取得了一定进展,部分实验可明显改善模型动物的认知障碍。 Vascular dementia(VD) is a kind of cognitive disorder caused by ischemic or hemorrhagic cerebrovascular diseases,global brain ischemia,or hypoxia.Conventional drug treatment is ineffective.Umbilical cord blood stem cells,having a strong ability of proliferation and differentiation,can be differentiated into neuron cells,thus to act on VD.Some progress has been made in research of umbilical cord blood stem cells in treating VD.Some experiments can significantly improve the cognitive impairment of animal models.
出处 《中国全科医学》 CAS CSCD 北大核心 2010年第5期561-563,共3页 Chinese General Practice
关键词 脐血干细胞 移植 血管性痴呆 Umbilical cord blood stem cell Transplantation Vascular dementia
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  • 1Lansdorp PM, Dragowska, Mayani H. Ontogeny - related changes in proliferative potential of human hematopoietic cells [J].J Exp Med, 1993, 178: 787-791.
  • 2Hao QL, Shah A J, Thiemann FT. A functional comparison of CD34^+ CD38^- Cells in cord blood and bone marrow [J]. Blood, 1995, 86, 3745 -3753.
  • 3迟作华,陆琰,张洹.体外诱导脐血间充质干细胞向胰岛β样细胞分化的初步研究[J].细胞生物学杂志,2008,30(3):383-386. 被引量:14
  • 4McGuckin CP, Forraz N, Allouard Q, et al. Umbilical cord blood stem cells can expand hematopoietic and neuroglial progenitors in vitro [J]. Exp Cell Res, 2004, 295 (2): 350 - 359.
  • 5喻永涛,惠国桢,陈镭,陆华,苗宗宁.人脐血间充质干细胞的分离培养与向神经元样细胞诱导分化的实验研究[J].苏州大学学报(医学版),2004,24(6):787-790. 被引量:14
  • 6金光鑫,吴德全.脐带血间充质干细胞研究进展[J].国际移植与血液净化杂志,2006,4(5):45-48. 被引量:11
  • 7Mohyeddin Bonab MA, Alimoghaddam KA, Goliaei ZA, et al. Which factors can affect cord blood variables? [ J ]. Transfusion 2004, 44 (5) : 690 - 693.
  • 8Makino S, Harada M, Akashi K, et al. A simplified method forcryopreservation of periph- eral blood stem ceils at -80 degrees C without rate - controlled freezing [ J ]. Bone Marrow Transplant, 1991, 8 (4): 239-244.
  • 9陈光明,王海鹰,张绍志,方立英,韩晓红.脐带血干细胞玻璃化保存研究[J].浙江大学学报(工学版),2007,41(5):804-808. 被引量:5
  • 10Mazurier F, Doedens M, Gan OI, et al. Rapid myeloeryth - roid repopulation after intrafemoral transplantation of NOD - SCID mice reveals a new class of human stern cells [J]. Nat Med, 2003, 9 (7): 959 - 963.

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