肺炎支原体抗体IgM阳性患儿831例临床分析

A Clinical Analysis of 831 Children with Positive Mycoplasma Pneumoniae IgM Antibody

目的分析肺炎支原体感染患儿的临床及实验室资料,为诊断和治疗肺炎支原体感染提供依据。方法采用ELISA法检测以发热、呼吸道疾病住院患儿肺炎支原体IgM,被动凝集法检测血清肺炎支原体混合抗体,透射比浊法检测C反应蛋白(CRP),半定量检测降钙素原(PCT),对其中831例肺炎支原体IgM阳性患儿分年龄段进行对比分析。结果肺炎支原体感染患儿男女构成间差异无统计学意义(P>0.05),而患儿的季节分布间差异有统计学意义(P<0.01)。肺炎支原体感染患儿中肺炎支原体肺炎占74.2%。肺炎支原体感染患儿血清CRP异常率48.2%与PCT的异常率18.3%比较,差异有统计学意义(P<0.01)。结论肺炎支原体感染的患儿以学龄儿童为主;在诊治时,不能仅局限于呼吸系统;肺炎支原体感染辅助诊断中PCT的临床意义优于CRP。

Objective To analyze the clinical and laboratory data of children infected with Mycoplasma pneumoniae （Mp） . Methods The clinical and laboratory data of 831 children with positive Mp IgM antibody from January 2007 to December 2007 were retrospectively analyzed. All patients were hospitalized with fever or respiratory diseases. Mycoplasma pneumoniae IgM was detected with ELISA. Mp mixed- antibody was detected with passive agglutination assay. C -reactive protein （CRP） was determined with transmission turbidimetry. Procalcitonin （PCT） was determined with quasi - quantitative method. Results The prevalence of Mp infection was not significantly different between male and female children （ P 〉 0. 05 ） , but was remarkably season -specific. Most children （74. 2% ） presented with mycoplasma] pneumoniae pneumonia. The abnormality rate （48.2%） of CRP was significantly higher than that （ 18.2% ） of PCT （P 〈 0. 01 ）. Conclusion Most Mp infections occur in school - aged children. Diagnosis and treatment of Mp infection should not be restricted only in the respiratory system. PCT is more valuable than CRP in the diagnosis of Mp infection.