巨细胞病毒感染诊断及治疗进展

Diagnosis and Treatment Progress of Cytomegalovirus Infection

巨细胞病毒(cytomegalovirus,CMV)感染在我国流行广泛,胎儿及免疫力低下的婴儿易受侵害。肝脏是巨细胞病毒感染的主要靶器官。此外,巨细胞病毒还可侵犯呼吸、神经、血液系统,严重者导致胎儿畸形,甚至危及患儿生命。巨细胞病毒感染在健康人群中多表现为亚临床不显性感染和潜伏感染。而孕期和儿童巨细胞病毒感染较为严重,是引起出生缺陷和各种不可逆损伤的重要因素。因此巨细胞病毒感染早期诊治的重要性越来越受到关注。本文对巨细胞病毒的诊断及治疗进展综述如下。

Cytomegalovirus （CMV） infection is widely prevalent in China. Fetuses and immunocompromised infants are susceptible to this disease. Liver is the main target, and respiratory, neurological, hemotological system can be involved as well. Sometimes it could he fatal. Cytomegalovirus infection among the healthy population usually manifest as subclinical or latent infection. However, the outcome of cytomegalovirus infection in the perinatal period and childhood could be severe. Perinatal cytomegalovirus infection is one of the main etiologies of birth defects and could cause irreversible lesions in the infants. The timing of cytomegalovirus infection in childhood usually takes place early, and the positive incidence of antibody is as high as eighty percent by the end of the first year. Therefore, early diagnosis and treatment of cytomegalovirus infection are more and more concerned. The authors reviewed the related literatures on the diagnosis and treatment of cvtomegalovirus infection.