血浆硫化氢水平与冠心病的相关性研究

The Analysis of the Correlation between Serum Hydrogen Sulfide and Coronary Heart Disease

目的观察不同类型冠心病(coronary heart disease,CHD)患者血浆硫化氢(H2S)水平的变化,研究其与CHD的相关性。方法100例冠心病患者分为稳定型组(SAP)20例,急性冠脉综合征组(ACS)60例,陈旧性心肌梗死组(OMI)20例,CHD中合并高血压患者的有48例;另设正常对照组30例。采用去蛋白法测定血浆H2S水平及酶联免疫吸附法测定血浆Hcy水平。结果①血浆H2S水平在CHD组低于NC组(P<0.01),其中ACS组显著低于SAP、NC组(P<0.01),ACS与OMI组无明显差异(P>0.05)。②直线相关性分析显示:H2S与Hcy水平之间、H2S水平与冠脉病变Gensini积分之间分别有显著相关性(r=-0.728和-0.795,P<0.01)。结论血浆H2S水平降低,与CHD患者的发生、发展相关,可能是预测易损斑块,反应CHD病情严重程度的敏感指标之一。

Objective To investigate the correlation between serum hydrogen su/fide （H2S） and coronary heart disease （CHD）. Methods 100 patients with CHD including 48 hypertensive,as study group were assigned into 3 subgroups according to stable angina pectoris （ SAP, n = 20 ）, acute coronary syndrome i ACS, n = 60 ）, and old myocardial infarction （ OMI, n = 20 ）. other 30 healthy persons as normal contral group （NC）. Plasma H2 S level was detected by spectrophotometer, Plasma Hey content was examined by ELISA. Results Plasma H2 S in patients with CHD [ （33.44 ± 12.09） μmol/L] were significantly reduced than that of normal group[ （52.41 ±11.67 ） μmol/L,P 〈 0. 01 ], plasma H2S level in subgroup of ACS significant differences from SAP [ （31.30±11.19 ） vs （41.96 ± 8.51 ） ~mol/L, P 〈 0. 01 ]. A negative correlation of H2S concentrations analyzed by linear regression with plasma Hey（r= -0.728,P〈0.01） ,and Gensini scores（r= -0.795,P〈0.01） respectively. Conclusion The decline of serum H2S was related to CHD; The level of serum H2S maybe one of the sensitive makers to recognize vulnerable plaque and evaluate the degree of crisis.